72601-82-2Relevant articles and documents
CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY
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Page/Page column 22-29, (2012/06/15)
Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.
Profiling of glycosidase activities using coumarin-conjugated glycoside cocktails
Park, Sungjin,Shin, Injae
, p. 619 - 622 (2007/10/03)
Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.