72624-66-9

Basic information

• Product Name: 6-Chlor-2-(dimethylamino)methyl-4-phenyl-chinazolin-3-oxid
• CAS NO: 72624-66-9
• Molecular Weight: 313.787
• Mol File: 72624-66-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-Chlor-2-(dimethylamino)methyl-4-phenyl-chinazolin-3-oxid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chlor-2-(dimethylamino)methyl-4-phenyl-chinazolin-3-oxid(72624-66-9)
• EPA Substance Registry System: 6-Chlor-2-(dimethylamino)methyl-4-phenyl-chinazolin-3-oxid(72624-66-9)

Safety Data

• Hazardous Substances Data: 72624-66-9(Hazardous Substances Data)

Upstream product

• 18097-52-4 2-amino-5-chlorobenzophenone oxime 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 5958-24-7 6-chloro-2-chloromethyl-4-phenylquinazoline-3-oxide 
• 124-40-3 dimethyl amine 

Relevant articles and documents

Mechanism of selective formation of 2-amino-substituted 1,4-benzodiazepin-4-oxides and 2-aminomethyl substituted quinazolin-3-oxides from chloromethyl quinazolin-N-oxides indications from perturbation theory

The o-amino-acetophenone and -benzophenone oximes 1a-c react with chloroacetyl chloride giving the 2-chloromethyl-quinazoline-3-oxides 6a-c. The mechanism is explained using the perturbation theory. With ammonia and N-prim. aliphatic amines, compounds 6a-c yield 1,4-benzodiazepines 16 and 17 as ring-enlarged products, with aromatic and with N-sec. aliphatic amines, quinazoline derivatives 10-13 are formed. The constitution of the heterocycles is proved by nmr spectroscopic methods. Selective formation of the heterocyclic products is explained with the relative thermodynamic stability of the corresponding 2-adducts 14.