72666-56-9

Basic information

• Product Name: Phosphine oxide, (2,5-dimethoxyphenyl)diphenyl-
• CAS NO: 72666-56-9
• Molecular Formula: C20H19O3P
• Molecular Weight: 338.343
• Mol File: 72666-56-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phosphine oxide, (2,5-dimethoxyphenyl)diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphine oxide, (2,5-dimethoxyphenyl)diphenyl-(72666-56-9)
• EPA Substance Registry System: Phosphine oxide, (2,5-dimethoxyphenyl)diphenyl-(72666-56-9)

Safety Data

• Hazardous Substances Data: 72666-56-9(Hazardous Substances Data)

Upstream product

• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 829-85-6 diphenylphosphane 
• 85417-48-7 1,4-dimethoxy-2-diphenylphosphinobenzene 
• 4559-70-0 Diphenylphosphine oxide 
• 150-78-7 1,4-dimethoxybezene 
• 1079-66-9 chloro-diphenylphosphine 
• 150-76-5 4-methoxy-phenol 
• 74-88-4 methyl iodide 
• 120726-60-5 (2-hydroxy-5-methoxyphenyl)diphenylphosphine oxide 
• 13291-46-8 (2,5-dihydroxyphenyl)diphenylphosphine oxide 

Downstream Products

• 140458-75-9 1-[2-(Diphenyl-phosphinoyl)-3,6-dimethoxy-phenyl]-isoquinoline 
• 120726-60-5 (2-hydroxy-5-methoxyphenyl)diphenylphosphine oxide 
• 140458-76-0 1-(2-Diphenylphosphanyl-3,6-dimethoxy-phenyl)-isoquinoline 
• 136202-13-6 2,2'-(diphenylphosphinoyl)-3,3',6,6'-tetramethoxybiphenyl 
• 136202-11-4 (S)-<3,6-dimethoxy-2-(diphenylphosphinoyl)benzyl>phenylethylamine 
• 765959-00-0 trifluoro-methanesulfonic acid 2-(diphenyl-phosphinoyl)-4-methoxy-phenyl ester 
• 765959-02-2 2-(diphenyl-phosphinoyl)-4-methoxy-biphenyl 
• 136202-08-9 1,4-dimethoxyphenylene-2,3-bis(diphenylphosphine oxide) 
• 136202-12-5 <3,6-dimethoxy-2-(diphenylphosphinoyl)phenyl>(2,3-dimethoxyphenyl)methanol 
• 136202-07-8 <3,6-dimethoxy-2-(phenylthio)phenyl>diphenylphosphine oxide 
• 136202-03-4 (2-chloro-3,6-dimethoxyphenyl)diphenylphosphine oxide 
• 136202-05-6 (3,6-dimethoxy-2-iodophenyl)diphenylphosphine oxide 
• 136202-04-5 (2-bromo-3,6-dimethoxyphenyl)diphenylphosphine oxide 
• 136202-02-3 C₂₀H₁₈⁽²⁾HO₃P 

Relevant articles and documents

Efficient potassium hydroxide promoted P-arylation of aryl halides with diphenylphosphine

A simple synthetic method of triarylphosphine compounds by KOH-promoted P-Arylation reaction of aryl halides with diphenylphosphine is presented. Notably, this transformation could smoothly proceed with high yields under transition-metal-free and mild reaction conditions. In addition, this protocol is valuable for industrial application due to the convenient operation and readily accessible aromatic halides. A possible explanation of the reaction mechanism was proposed based on the experimental data.

Synthesis of ortho-phenyl substituted MeO-BIPHEP ligand and its application in Rh-catalyzed asymmetric hydrogenation

A new BIPHEP-type ligand with phenyl groups at the 3,3′-positions, o-Ph-MeO-BIPHEP 3 was prepared. This ligand afforded excellent enantioselectivities when used in the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid derivatives. The strong influence of o-phenyl groups of the ligand on the enantioselectivities of the reaction has been demonstrated by a comparison with its parent ligand MeO-BIPHEP.

Selective Ortho Lithiation of (2,5-Dimethoxyphenyl)diphenylphosphine Oxide and Trapping of the Resulting Aryllithium with Electrophiles

The title compound undergoes predominant 6-lithiation, ortho to the methoxy and phosphinoyl groups, on reaction with t-BuLi in THF under conditions of thermodynamic control at low temperature.The organolithium compound is stable at least to 0 deg C and can be trapped by a range of electrophiles to give the corresponding tetrasubstituted (diphenylphosphinoyl)arenes in moderate to good yield.The iodide formed by this sequence undergoes Ullman coupling to the diphenyl, which exhibits a novel restricted rotation phenomenon, in good yield under mild conditions. (2,5-Dimethoxyphenyl)diphenylphosphine sulfide lithiates exclusively at the 4-position under the same conditions, whilst the corresponding phosphine is unreactive.