72676-66-5 Usage
Antineoplastic activity
The compound has the potential to inhibit the growth of cancer cells.
Cytotoxic alkylating agent
ACNU is a cytotoxic agent that forms highly reactive carbonium ions, which can alkylate DNA.
DNA cross-linking
The alkylation of DNA by ACNU leads to the formation of cross-links between DNA strands, which inhibits DNA replication and RNA synthesis.
Inhibition of tumor cell growth
By disrupting DNA replication and RNA synthesis, ACNU ultimately inhibits the growth of tumor cells.
Treatment of various cancers
ACNU has been studied for its potential use in the treatment of different types of cancer, including brain tumors, malignant gliomas, and metastatic brain tumors.
Administration by intravenous infusion
The compound is typically administered through an intravenous infusion.
Preclinical and clinical trials
ACNU has shown promise in preclinical and clinical trials for its anti-cancer properties.
Side effects
The use of ACNU has been associated with side effects such as myelosuppression (reduction in the production of blood cells) and gastrointestinal toxicity (damage to the digestive system).
Check Digit Verification of cas no
The CAS Registry Mumber 72676-66-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,6,7 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 72676-66:
(7*7)+(6*2)+(5*6)+(4*7)+(3*6)+(2*6)+(1*6)=155
155 % 10 = 5
So 72676-66-5 is a valid CAS Registry Number.
72676-66-5Relevant articles and documents
Synthesis and Anticancer Activity of Nitrosourea Derivatives of Phensuximide
Crider, A. Michael,Kolczynski, Thomas M.,Yates, Kathleen M.
, p. 324 - 326 (2007/10/02)
Nitrosourea derivatives 9-13 which utilize phensuximide (1) as the carrier were synthesized as potential central nervous system antitumor agents.The N-(2-chloroethyl)-N-nitrosourea 13 was active in the mouse ependymoblastoma brain-tumor system, as well as
