72676-82-5

Basic information

• Product Name: ethyl α-(2,5-dimethoxybenzylidene)acetoacetate
• Synonyms: ethyl α-(2,5-dimethoxybenzylidene)acetoacetate
• CAS NO: 72676-82-5
• Molecular Weight: 278.305
• Mol File: 72676-82-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl α-(2,5-dimethoxybenzylidene)acetoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl α-(2,5-dimethoxybenzylidene)acetoacetate(72676-82-5)
• EPA Substance Registry System: ethyl α-(2,5-dimethoxybenzylidene)acetoacetate(72676-82-5)

Safety Data

• Hazardous Substances Data: 72676-82-5(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 110-89-4 piperidine 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 72676-83-6 ethyl α-acetyl-β-(2,5-dimethoxyphenyl)propionate 
• 72732-56-0 piritrexim 
• 72676-85-8 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine 
• 72676-84-7 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine 

Relevant articles and documents

Synthesis and Antitumor Activity of 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyridopyrimidine

The synthesis of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyridopyrimidine (BW301U, 7) by a route that has general applicability to the preparation of many 6-(substituted benzyl)-5-methylpyridopyrimidines is described.The key intermediate, 2,4-diamino-7,8-dihydro-6-(2,5-dimethoxybenzyl)-5-methyl-7-oxopyridopyrimidine (4), is converted to the 7-chloro compound 5 by treatment with a 1:1 complex of N,N-dimethylformamide-thionyl chloride, and 5 is hydrogenolyzed with palladium on charcoal in the presence of potassium hydroxide to yield 7.BW301U is a potent lipid-soluble inhibitor of mammalian dihydrofolate reductase and has significant activity against the Walker 256 carcinosarcoma in rats.

Treatment with dialkoxy pyridopyrimidines

Potent psoriasis activity in combination with low inhibition of histamine N-methyltransferase has been found in a class of 2,4-diamino-6-(2,5-dialkoxybenzyl)-5-methylpyrido[2,3-d]pyrimidines.