72687-16-2Relevant articles and documents
Synthesis of 5--2'-deoxyuridine, the Corresponding Sulfoxide and Sulfone, and Their 5'-Phosphates: Antiviral Effects and Thymidylate Synthetase Inhibition
Schmidt, Charles L.,Chang, Charles T.-C.,Clercq, Erik De,Descamps, Johan,Mertes, Mathias P.
, p. 252 - 256 (1980)
Substitution on the α position of thymidine with methylthio (3) and methylsylfonyl (5) groups gave antiviral agents that were specific and relatively nontoxic inhibitors of herpes simplex virus replication in cell culture.The thioether (3) was effective a