727-62-8

Basic information

• Product Name: 2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE
• Synonyms: 4(3H)-Quinazolinone, 2-chloro-3-phenyl-;2-chloro-3-phenylquinazoline-4-(3H)-one
• CAS NO: 727-62-8
• Molecular Formula: C₁₄H₉ClN₂O
• Molecular Weight: 256.69
• Mol File: 727-62-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 411.2 °C at 760 mmHg
• Flash Point: 202.5 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 5.7E-07mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE(727-62-8)
• EPA Substance Registry System: 2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE(727-62-8)

Safety Data

• Hazardous Substances Data: 727-62-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-phenylquinazolin-4(3H)-one is a chemical compound that belongs to the quinazolinone class of organic compounds. It is a slightly yellow solid that is commonly used in the field of medicinal chemistry for the synthesis of various pharmaceuticals. 2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE has been studied for its potential biological activities, including as an antitumor agent, an anti-inflammatory agent, and an antifungal agent. It is also used as a chemical intermediate in the production of other organic compounds. 2-Chloro-3-phenylquinazolin-4(3H)-one is an important building block in the synthesis of potential drug candidates and has shown promising results in various preclinical studies.

InChI:InChI=1/C14H9ClN2O/c15-14-16-12-9-5-4-8-11(12)13(18)17(14)10-6-2-1-3-7-10/h1-9H

Upstream product

• 603-23-6 3-phenyl-2,4-(1H,3H)-quinazolinedione 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 118-92-3 anthranilic acid 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 741-76-4 2-(morpholin-4-yl)-3-phenylquinazolin-4(3H)-one 
• 10204-16-7 2-(butylamino)-3-phenylquinazolin-4(3H)-one 
• 76462-02-7 3a-Ethoxy-2,4-diphenyl-3a,4-dihydro-oxazolo[3,2-a]quinazoline-1,5-dione 
• 59342-38-0 4-phenyl-4,5-dihydrotetrazolo<1,2-a>-5-quinazolone 
• 731-52-2 2-hydrazino-3-phenyl-3H-quinazolin-4-one 
• 76462-03-8 1-Benzylsulfanyl-4-phenyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 
• 67811-46-5 4-phenyl-5-oxo-4,5-dihydro-s-triazolo-<4,3-a>-quinazoline 
• 67442-90-4 4-phenyl-5-oxo-1-thioxo-1,2,4,5-tetrahydro-s-triazolo<4,3-a>-quinazoline 
• 3318-07-8 benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone 
• 55536-48-6 1-benzyl-2,3-dihydroimidazo[2,1-b]quinazolin-5(1H)-one 
• 32725-30-7 2,3-dihydroimidazo<2,1-b>quinazolin-5(1H)-one 

Relevant articles and documents

2-HETEROARYL AMINOQUINAZOLINONE DERIVATIVE

Provided is a 2-heteroaryl aminoquinazolinone derivative, which is a compound represented by formula (1): or a pharmaceutically acceptable salt thereof wherein X1 represents CR1 or N, X2 represents CR2 or N, X3 represents CR3 or N, X4 represents CR4 or N, Y represents optionally substituted C1-6 alkyl, an optionally substituted C3-10 alicyclic group, an optionally substituted 4- to 10-membered nitrogen-containing non-aryl heterocycle, optionally substituted C6-10 aryl, or optionally substituted 5- to 10-membered heteroaryl, Z represents optionally substituted 6- to 10-membered heteroaryl, and R1, R2, R3, and R4 each independently represent a hydrogen atom, halogen, cyano, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkoxy, or the like.

2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone compounds and application thereof

The invention belongs to the technical field of medicines and relates to 2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone compounds and an application thereof. 2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone derivatives comprise stereisomers and pharmaceutically applicable salts of the compounds and have the general structural formula shown in the description, wherein R is described inthe claims and description. The 2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone derivatives and pharmaceutically applicable acid-added salts of the compounds can be combined with existing medicines or used separately to serve as influenza virus inhibitors to treat influenza and have better curative effects on various type-A influenza in particular.

Fungicidal azole compounds

Compounds of the formula: STR1 where: A is oxygen or sulphur; R1 is phenyl or substituted phenyl in which the substituent is at least one member selected from the group consisting of halogen, C1-6 -alkyl, C1-6 -haloalkyl, C1-6 -alkoxy, C1-6 -haloalkoxy and nitro; R2 is 1-imidazoly of 1,2,4-triazol-1-yl; and R3, R4, R5 and R6, which may be the same or different, are each hydrogen, halo, C1-6 -alkyl or C1-6 -alkoxy have valuable fungicidal properties.