727-80-0Relevant articles and documents
Thermal, kinetic, spectroscopic studies and anti-microbial, anti-tuberculosis, anti-oxidant properties of clioquinol and benzo-coumarin derivatives mixed complexes with copper ion
Dholariya, Hitesh R.,Patel, Ketan S.,Patel, Jiten C.,Patel, Atul K.,Patel, Kanuprasad D.
, p. 5848 - 5860 (2013)
A series of six Cu(II) complexes of clioquinol with benzo-coumarin derivatives have been synthesized. Physico-chemical, spectroscopic, and thermal properties of the complexes have been studied on the basis of infrared spectra, mass spectra, NMR spectra, e
Turn on fluorescent chemosensor containing rhodamine B fluorophore for selective sensing and in vivo fluorescent imaging of Fe3+ ions in HeLa cell line and zebrafish
Vijay, Natarajan,Wu, Shu Pao,Velmathi, Sivan
, (2019)
Rhodamine dyes are utilized effectively as a chemosensor to monitor biologically important metal ions and effectively applied for fluorescent imaging studies in living systems. Herein, rhodamine-B armed fluorescent chemosensor (RhBNC) was designed and synthesized by condensation reaction between rhodamine B hydrazide and naphthyl chromone with ONO binding site in good yield. Upon sensing study towards metal ions, the probe showed selective turn-on fluorescent change for Fe3+ over other cations even in the presence of competing trivalent metal ions as well. The fluorescence switch is “on” when Fe3+ ions binds to RhBNC with orange fluorescence. The probe can detect lower concentration of Fe3+ ions with detection limit of 0.16 μM. Due to its lower detection limit; it can be applied to monitor Fe3+ ion presence in a living system by fluorescent imaging technique. The probe was employed effectively to ascertain the presence of Fe3+ and to image Fe3+ ions in HeLa cell line and zebrafish.
Half-sandwich platinum group metal complexes containing coumarin-N-acylhydrazone hybrid ligands: Synthesis and biological evaluation studies
Dkhar, Lincoln,Kaminsky, Werner,Kollipara, Mohan Rao,Nongpiur, Carley Giffert L.,Poluri, Krishna Mohan,Tripathi, Deepak Kumar
, (2021)
A series of half-sandwich platinum group metal complexes containing coumarin-N-acylhydrazone ligands have been prepared. The metal precursors of the type [(p-cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) and coumarin-N-acylhydrazone ligands (L1, L2 and L3) were reacted in the ratio of 1:2 (M:L), forming neutral bidentate (N ∩ O) complexes (1–9). The complexes are of the general formula [(arene)M{κ2(N∩O)L}Cl]. All these complexes have been characterized by analytical, spectroscopic and single-crystal X-ray diffraction studies. The complexes and ligands were then carried out for antibacterial, antioxidant and DNA binding studies. The results show that both ligands and complexes possess potent antibacterial and antioxidant properties. ___________________________________________________________________________
Novel reaction-based chemosensor for Al3+ detection using hybrid framework of chalcone-coumarin in aqueous phase and its anticancer activity
Chan, Yi-Huan,Sasidharan, Sreenivasan,Shanmugapriya,Yeap, Guan-Yeow
, (2021/11/30)
A new water-soluble chemosensor (L) made up by chalcone-coumarin hybrid framework was synthesized and the photophysical properties of probe L towards heavy metal ions were observed by naked-eye along with UV-vis and NMR spectroscopic techniques. The newly obtained chemosensor L showed an apparent colour change from yellow to cyan due to the presence of a new hump at 610.2 nm in UV-vis spectrum which can be ascribed to the affinity of L towards the aluminium Al3+ ion. The receptor L displays excellent selectivity and sensitivity towards Al3+ ion with the detection limit of 2.21 × 10?5 M. The stoichiometric ratio and association constant for the L-Al3+ complex are 2:1 and 5.91 M-2, respectively. The IC50 value of 15.38 μM as shown by probe L indicates that it exhibits strong anticancer properties.
A chemodosimeter for selective fluorogenic and chromogenic detection of phenylenediamine isomers
Deepa, Appadurai,Lavanya, Raja,Lee, Shyi-Long,Mathivanan, Venkatesan,Padmini, Vediappen,Ramamoorthy, Jaganathan,Sathya, Vijayakumar,Srinivasadesikan, Venkatesan
, (2022/01/19)
A chromogenic and fluorogenic active coumarin-based chemodosimeter (DP21) has been synthesized. The probe shows remarkable fluorescent intensity with phenylenediamine isomers (PDA) such as ortho-phenylenediamine (OPD) and para-phenylenediamine (PPD) in the presence of competitive species. The probe changes from light yellow to reddish brown and dark yellow with OPD and PPD, respectively, through naked eye. The interaction?of lone pair electrons?in carbonyl group present in DP21 with amino group of OPD and PPD?shows?the intermolecular hydrogen bonding. The PDA isomers can be detected selectively in the presence of other interfering organic and inorganic amines by the DP21. It shows excellent low detection limit (LOD) for OPD and PPD is 0.19?nM and 0.4 nM respectively. Graphical abstract: [Figure not available: see fulltext.]
