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72724-00-6

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72724-00-6 Usage

Chemical structure

Substituted benzene derivative
The compound is derived from benzene, a basic aromatic ring structure, with additional functional groups attached.

Functional groups

Benzyl ether and bromomethyl groups
The compound contains a benzyl ether group (C6H5-CH2-O-) and a bromomethyl group (-CH2Br) attached to the benzene ring.

Synonyms

4-(bromomethyl)-1-benzyloxy-2-methoxybenzene
The compound is also known by this alternative name, which highlights the positions of the functional groups on the benzene ring.

Applications

Organic synthesis and pharmaceutical research
The compound is commonly used in the synthesis of more complex organic compounds and is also utilized in the development of drug candidates.

Potential uses

Development of drug candidates and production of fine chemicals
Due to its unique structure and functional groups, the compound has potential applications in the pharmaceutical industry and the production of specialty chemicals.

Versatility

Building block for complex compound synthesis
The compound's structure and functional groups make it a valuable starting material for the synthesis of more complex organic molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 72724-00-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,7,2 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 72724-00:
(7*7)+(6*2)+(5*7)+(4*2)+(3*4)+(2*0)+(1*0)=116
116 % 10 = 6
So 72724-00-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H15BrO2/c1-17-15-9-13(10-16)7-8-14(15)18-11-12-5-3-2-4-6-12/h2-9H,10-11H2,1H3

72724-00-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(bromomethyl)-2-methoxy-1-phenylmethoxybenzene

1.2 Other means of identification

Product number -
Other names 3-methoxy-4-benzoyloxybenzyl bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:72724-00-6 SDS

72724-00-6Relevant articles and documents

Application of gastrodia elata bl derived derivative to preparation of medicine for treating acute or chronic pain

-

Paragraph 0094; 0098, (2021/01/20)

The invention discloses application of gastrodia elata bl derived derivatives to preparation of a medicine for treating the acute or chronic pain, in particular to compounds as shown in general formulas (I), (II) and (III) and application of pharmaceutically acceptable salt thereof to preparation of the medicine for preventing and/or treating the acute or chronic pain, discloses a preparation method of the compounds, and belongs to the technical field of medicine.

Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors

Butts, Craig P.,Collingridge, Graham L.,Jane, David E.,Mallah, Shahida,Molnár, Elek,Re?nik, Lisa-Maria,Thatcher, Robert J.,Willis, Christine L.

supporting information, p. 9154 - 9162 (2021/11/16)

(-)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay. In general, these compounds showed antagonist activity at both receptors with greater activity evident at AMPARs. Schild analysis indicates that a spirocyclic analogue 6c acts as a non-competitive antagonist. Molecular docking studies in which 6c was docked into the X-ray crystal structure of the GluA2 tetramer suggest that (-)-arctigenin and its analogues bind in the transmembrane domain in a similar manner to the known AMPA receptor non-competitive antagonists GYKI53655 and the antiepileptic drug perampanel. The arctigenin derivatives described herein may serve as novel leads for the development of drugs for the treatment of epilepsy. This journal is

Versatile and Enantioselective Total Synthesis of Naturally Active Gnetulin

Shang, Changhui,Kang, Yulong,Yang, Qingyun,Zhu, Qibin,Yao, Chunsuo

supporting information, p. 3768 - 3776 (2019/07/12)

A versatile and efficient enantioselective total synthesis of natural isorhapontigenin dimers (?)-gnetulin, (+)-gnetulin, and (±)-gentulin was proposed. By using this method, we were able to synthesize the dimers from commercial available achiral materials in 13 steps, and achieve a 7%–9% overall yield with >98% enantiomeric excess. The key features of the method include the stereocontrolled enantioselective conjugate reduction of 3-arylindenone catalyzed by methyloxazaborolidine (Me-CBS) and the α-arylation of 3-aryl-1-indanones. Benzylic sulfide was accessed in excellent yield through the InCl3-catalyzed thio-etherification reaction between 2,3-diarylindanol and bezylic thiol. The method is practical and might thus be useful in the enantioselective synthesis of the optical antipodes of natural indane derivatives with or without methoxy groups at aromatic rings. (Figure presented.).

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