7273-36-1

Basic information

• Product Name: 7-benzyl-1,3-dimethyl-8-phenyl-3,7-dihydro-1H-purine-2,6-dione
• Synonyms: 7-benzyl-1,3-dimethyl-8-phenyl-3,7-dihydro-1H-purine-2,6-dione
• CAS NO: 7273-36-1
• Molecular Weight: 346.389
• Mol File: 7273-36-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 7-benzyl-1,3-dimethyl-8-phenyl-3,7-dihydro-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyl-1,3-dimethyl-8-phenyl-3,7-dihydro-1H-purine-2,6-dione(7273-36-1)
• EPA Substance Registry System: 7-benzyl-1,3-dimethyl-8-phenyl-3,7-dihydro-1H-purine-2,6-dione(7273-36-1)

Safety Data

• Hazardous Substances Data: 7273-36-1(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 15421-92-8 N-benzylbenzamidine 
• 591-50-4 iodobenzene 
• 1807-85-8 7-benzyltheophylline 
• 71-43-2 benzene 
• 58-55-9 theophylline 
• 100-39-0 benzyl bromide 
• 10381-75-6 8-bromotheophylline 
• 85-18-7 8-chlorotheophylline 
• 70404-23-8 7-benzyl-8-bromo-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 
• 98-80-6 phenylboronic acid 
• 109286-40-0 7-benzyl-8-chloro-1,3-dimethyl-1,3,7-trihydropurine-2,6-dione 

Relevant articles and documents

Copper-Catalyzed Intramolecular C-H Amination: A New Entry to Substituted Xanthine Derivatives

Catalytic synthesis of xanthines was achieved in the presence of a copper catalyst. The process involves copper-catalyzed intramolecular C-H amination of benzamidines that possess a uracil moiety and produces variously substituted xanthines generally in good to high yields. This work introduces a new, facile approach to polysubstituted xanthine compounds..

Synthesis and characterization of amino-NHC coinage metal complexes and application for C-H activation of caffeine

This paper describes the synthesis and characterization of silver, copper and gold complexes supported by several amino-NHC ligands with different amino side arms. The transmetallation process using silver-NHC complexes can be used to prepare amino-NHC copper and gold complexes easily in high yield. In addition, the catalytic activities of copper complexes are examined for arylation of caffeine via C-H bond activation.

Synthesis of 8-substituted xanthine derivatives by Suzuki cross-coupling reaction

A Suzuki cross-coupling reaction procedure was developed to prepare 8-substituted 3,7-dihydropurine-2,6-dione (xanthine) derivatives. 8-Halogen-substituted xanthines were reacted with phenyl- and styrylboronic acids. The best results were obtained using tetrakis(triphenylphosphine)palladium(0) and tripotassium phosphate in dimethylformamide. The developed procedure allows for a convergent synthesis of pharmacologically active 8-substituted xanthine derivatives.