72748-98-2

Basic information

• Product Name: (R)-2-Methoxymethyl-1-nitroso-pyrrolidine
• Synonyms: (R)-2-Methoxymethyl-1-nitroso-pyrrolidine
• CAS NO: 72748-98-2
• Molecular Weight: 144.173
• Mol File: 72748-98-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-Methoxymethyl-1-nitroso-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Methoxymethyl-1-nitroso-pyrrolidine(72748-98-2)
• EPA Substance Registry System: (R)-2-Methoxymethyl-1-nitroso-pyrrolidine(72748-98-2)

Safety Data

• Hazardous Substances Data: 72748-98-2(Hazardous Substances Data)

Upstream product

• 72748-99-3 (R)-1-Amino-2-(methoxymethyl)pyrrolidine 
• 118535-92-5 (S)-2-[(Z)-(R)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1,2-diphenyl-ethanol 

Downstream Products

• 72748-99-3 (R)-1-Amino-2-(methoxymethyl)pyrrolidine 

Relevant articles and documents

ENANTIOSELECTIVE SYNTHESIS OF PROTECTED α-HYDROXY ALDEHYDES AND KETONES VIA HYDROXYLATION OF METALATED CHIRAL HYDRAZONES

α-Benzyloxy aldehydes and α-acetoxy ketones 4 of high enantiomeric purity are prepared in good overall yields via oxaziridine mediated hydroxylation of chiral hydrazone azaenolates.As auxiliaries novel proline derived hydrazine reagents 5 are used.

ASYMMETRIC SYNTHESIS OF β-SUBSTITUTED δ-KETOESTERS VIA MICHAEL-ADDITIONS OF SAMP/RAMP-HYDRAZONES TO α,β-UNSATURATED ESTERS, VIRTUALLY COMPLETE 1.6-ASYMMETRIC INDUCTION

A simple and efficient 3-step asymmetric synthesis of β-substituted δ-ketoesters 3 in 45-62percent overall chemical yield and >=96-ca.100percent ee is described.The key step is an asymmetric Michael-addition of lithiated methylketone-SAMP- or RAMP-hydrazones to α,β-unsaturated esters 2 with virtually complete 1.6-asymmetric induction.