72756-21-9

Basic information

• Product Name: Valine, N-benzoyl-3-methyl-
• CAS NO: 72756-21-9
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Mol File: 72756-21-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Valine, N-benzoyl-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Valine, N-benzoyl-3-methyl-(72756-21-9)
• EPA Substance Registry System: Valine, N-benzoyl-3-methyl-(72756-21-9)

Safety Data

• Hazardous Substances Data: 72756-21-9(Hazardous Substances Data)

Upstream product

• 92195-63-6 N-(2,2-dimethyl-1-phenylpropyl)acetamide 
• 22146-58-3 (+/-)-2-acetylamino-3,3-dimethylbutyric acid 
• 98-88-4 benzoyl chloride 
• 33105-81-6 2-amino-3,3-dimethylbutanoic acid 

Downstream Products

• 71953-55-4 2-phenyl-4-tert-butyloxazolin-5(4H)-one 
• 65718-51-6 (2S)-methyl 2-benzoylamino-3,3-dimethylbutanoate 
• 147701-18-6 (R)-2-Benzoylamino-3,3-dimethyl-butyric acid methyl ester 
• 121225-32-9 Bz-D-Tle-L-Pro-OMe 
• 121225-33-0 Bz-L-Tle-L-Pro-OMe 
• 128647-45-0 C₂₃H₂₈N₂O₄ 
• 128647-43-8 C₂₀H₃₀N₂O₄ 
• 128647-42-7 C₁₉H₂₈N₂O₄ 
• 128647-41-6 C₁₇H₂₄N₂O₄ 
• 919112-89-3 rac-2-benzoylamino-3,3-dimethylbutyric acid allyl ester 

Relevant articles and documents

Peptide-catalyzed conversion of racemic oxazol-5(4 H)-ones into enantiomerically enriched α-amino acid derivatives

We report the development and optimization of a tetrapeptide that catalyzes the methanolytic dynamic kinetic resolution of oxazol-5(4H)-ones (azlactones) with high levels of enantioinduction. Oxazolones possessing benzylic-type substituents were found to perform better than others, providing methyl ester products in 88:12 to 98:2 er. The mechanism of this peptide-catalyzed process was investigated through truncation studies and competition experiments. High-field NOESY analysis was performed to elucidate the solution-phase structure of the peptide, and we present a plausible model for catalysis.

Potassium channel openers

Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Method for preparing tert-leucine and analogues thereof in enantiomeric form and intermediates therein

Azlactone (3), or the opposite enantiomer thereof, undergoes biotransformation, using suitable enzymatic activity, in the presence of a compound YH to form a N-acyl-amino acid (2), wherein R1, R2 and R3 are each not hydrogen and are independently selected from groups containing up to 20 carbon atoms, optionally with any combination of R1, R2 and R3 being joined together to form at least one ring, X is selected from groups containing up to 20 carbon atoms, and Y is selected from the group consisting of —OH, -Oalkyl and -Nalkyl. Amino acid (1), or the opposite enantiomer thereof, can be prepared in high enantiomeric excess from N-acyl amino acid (2), by converting Y to OH.