72803-02-2

Basic information

• Product Name: Darodipine
• Synonyms: Darodipine;4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester;PY-108063;PY-108068;PY-108-068;Darodipine(PY-108068)
• CAS NO: 72803-02-2
• Molecular Formula: C19H21N3O5
• Molecular Weight: 371.39
• Mol File: 72803-02-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 507.3°C at 760 mmHg
• Flash Point: 260.6°C
• Appearance: /
• Density: 1.251g/cm³
• Vapor Pressure: 2.06E-10mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Darodipine(CAS DataBase Reference)
• NIST Chemistry Reference: Darodipine(72803-02-2)
• EPA Substance Registry System: Darodipine(72803-02-2)

Safety Data

• Hazardous Substances Data: 72803-02-2(Hazardous Substances Data)

Usage

Description

Darodipine is a calcium channel antagonist, which is a type of medication that functions by blocking the action of calcium ions in certain heart and blood vessel cells. This action leads to a relaxation of the blood vessels and a decrease in blood pressure, making it a useful compound for treating various cardiovascular conditions.

Uses

Used in Pharmaceutical Industry:
Darodipine is used as an antihypertensive agent for the treatment of high blood pressure. By acting as a calcium channel antagonist, it helps to relax the blood vessels, allowing for better blood flow and a reduction in blood pressure.
Used in Respiratory Therapy:
Darodipine is used as a bronchodilator to help open up the airways in individuals with respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD). This application aids in making it easier for patients to breathe by relaxing the muscles around the airways.
Used in Cardiovascular Treatment:
Darodipine is used as a vasodilator in the treatment of various cardiovascular diseases. Its ability to relax blood vessels and improve blood flow makes it a valuable tool in managing conditions like angina, peripheral artery disease, and certain heart rhythm disorders.

InChI:InChI=1/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3

Upstream product

• 626-34-6 ethyl aminocrotonate 
• 82886-02-0 ethyl 2-(2,1,3-benzoxadiazol-4-ylmethylene)acetoacetate 
• 103785-46-2 2-(Benzo[1,2,5]oxadiazol-4-yl-bromo-methyl)-3-oxo-butyric acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 32863-30-2 4-(bromomethyl)benzo[c][1,2,5]oxadiazole 
• 103785-43-9 ethyl 2-(2,1,3-benzoxadiazol-4-ylmethyl)acetoacetate 
• 32863-32-4 benzo[c][1,2,5]oxadiazole-4-carbaldehyde 
• 4887-83-6 4-methylbenzimidazole 

Relevant articles and documents

A preparation containing [...] method for synthesizing of antihypertensive medicines we surround class

The invention relates to a synthesis method for preparing an antihypertensive medicine having a benzofuroxan ring. In the method, 4-methylbenzofuroxan is used as a raw material, the 2,1,3-benzoxadiazole-4-aldehyde serving as an important intermediate is prepared by bromination and oxidation reactions, and the 2,1,3-benzoxadiazole-4-aldehyde and acetoacetic ester undergo a Hantzsch reaction to form the target compound. Compared with other processes, the method has the characteristics of mild reaction conditions, simple and efficient operation, high yield and the like and has a certain industrial production prospect.

Synthesis of asymmetric 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates with vasodilating and antihypertensive activities

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