72807-92-2 Usage
Description
Deoxydihydroqinghaosu, also known as DDQ, is a synthetic compound with potent antimalarial and potential antitumor properties. It is characterized by its ability to induce oxidative stress in microendothelial cells, which can be modulated by hypoxia. This unique characteristic makes it a promising candidate for various applications in the medical field.
Uses
Used in Antimalarial Applications:
Deoxydihydroqinghaosu is used as an antimalarial agent for its ability to effectively combat malaria-causing parasites. Its mechanism of action involves inducing oxidative stress in the parasites, leading to their destruction and preventing the progression of the disease.
Used in Antitumor Applications:
Deoxydihydroqinghaosu is used as a potential antitumor agent, particularly in the study of its effects on microendothelial cells. deoxydihydroqinghaosu's ability to induce oxidative stress can be modulated by hypoxia, making it a promising candidate for cancer research and treatment development.
Used in Biological Studies:
Deoxydihydroqinghaosu is used as a research tool in various biological studies, particularly those focusing on the effects of oxidative stress on microendothelial cells. Its unique properties allow researchers to investigate the underlying mechanisms of cell damage and potential therapeutic approaches for various diseases, including cancer and malaria.
Check Digit Verification of cas no
The CAS Registry Mumber 72807-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,8,0 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 72807-92:
(7*7)+(6*2)+(5*8)+(4*0)+(3*7)+(2*9)+(1*2)=142
142 % 10 = 2
So 72807-92-2 is a valid CAS Registry Number.
72807-92-2Relevant articles and documents
Biomimetic metabolism of artelinic acid by chemical cytochrome P-450 model systems
Idowu, Olutosin R.,Lin, Ai J.,Grace, James M.,Peggins, James O.
, p. 1449 - 1454 (1997)
Purpose. To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining authentic samples of the putative metabolites necessary for identification of the mammalian metabolites of artelinic acid. Methods. Ar
The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)
Haynes, Richard K.,Vonwiller, Simone C.
, p. 253 - 256 (2007/10/02)
With hemin [chlorprotoporphyrin IX iron(III)] or hemin/cysteine in aqueous MeCN, oxygen loss from the peroxide bridge of qinghaosu takes place to give a precursor to desoxoqinghaosu, a known malaria-inactive metabolite, in low yield. Ring-opened forms of
