72826-67-6

Basic information

• Product Name: 2-(linoleoylamino)-1,3-propanediol
• Synonyms: 2-(linoleoylamino)-1,3-propanediol
• CAS NO: 72826-67-6
• Molecular Formula: C21H39 N O3
• Molecular Weight: 0
• Mol File: 72826-67-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 548.2°C at 760 mmHg
• Flash Point: 285.3°C
• Appearance: /
• Density: 0.971g/cm³
• Vapor Pressure: 2.65E-14mmHg at 25°C
• Refractive Index: 1.495
• CAS DataBase Reference: 2-(linoleoylamino)-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(linoleoylamino)-1,3-propanediol(72826-67-6)
• EPA Substance Registry System: 2-(linoleoylamino)-1,3-propanediol(72826-67-6)

Safety Data

• Hazardous Substances Data: 72826-67-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(25)22-20(18-23)19-24/h6-7,9-10,20,23-24H,2-5,8,11-19H2,1H3,(H,22,25)/b7-6-,10-9-

Upstream product

• 7459-33-8 linoleyl chloride 
• 534-03-2 serinol 
• 60-33-3 linoleic acid 

Relevant articles and documents

GLYCEROL COMPOUNDS AND METHODS OF USE

Provided herein, inter alia, are compounds of fatty acid glycerol derivatives and compositions including the same.

Novel polyphenols that inhibit colon cancer cell growth affecting cancer cell metabolisms

New series of polyphenols with a hydrophilic galloyl-based head and a hydrophobic N-acyl tail, linked through a serinol moiety, have been synthesized and tested against colon cancer cell growth. Our structure activity relationship studies revealed that galloyl moieties are essential for growth inhibition. Moreover, the length of the N-acyl chain is crucial for the activity. Introduction of a (Z) double bond in the acyl chain increased the anticancer properties. Our findings demonstrate that 16, the most potent compound within this series, has inhibitory effects on colon cancer cell growth and metabolism (glycolysis and mitochondrial respiration) at the same time that it activates 59AMP-activated kinase (AMPK) and induces apoptotic cell death. Based on these results, we propose that 16 might reprogram colon cancer cell metabolism through AMPK activation. This might lead to alterations on cancer cell bioenergy compromising cancer cell viability. Importantly, these antiproliferative and proapoptotic effects are selective for cancer cells. Accordingly, these results indicate that 16, with an unsaturated C18 chain, might be a useful prototype for the development of novel colon cancer cell growth inhibitors affecting cell metabolism.