72851-19-5

Basic information

• Product Name: 3-(DIMETHYLAMINO)-1-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPEN-1-ONE
• Synonyms: 3-(DIMETHYLAMINO)-1-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPEN-1-ONE
• CAS NO: 72851-19-5
• Molecular Formula: C₁₂H₁₂F₃NO
• Molecular Weight: 243.22
• Mol File: 72851-19-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 61-62
• Boiling Point: 280.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.187±0.06 g/cm3(Predicted)
• PKA: 6.31±0.70(Predicted)
• CAS DataBase Reference: 3-(DIMETHYLAMINO)-1-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIMETHYLAMINO)-1-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPEN-1-ONE(72851-19-5)
• EPA Substance Registry System: 3-(DIMETHYLAMINO)-1-[3-(TRIFLUOROMETHYL)PHENYL]-2-PROPEN-1-ONE(72851-19-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 72851-19-5(Hazardous Substances Data)

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 18503-90-7 N,N-dimethylformamide di-n-butyl acetal 
• 350-03-8 methyl-3-pyridylketone 
• 2016-05-9 dimethylformamide di-cyclohexyl acetal 

Downstream Products

• 112778-91-3 2-<3-(trifuoromethyl)phenyl>pyrimido<1,2-a>benzimidazole 
• 112778-90-2 4-<3-(trifuoromethyl)phenyl>pyrimido<1,2-a>benzimidazole 
• 159224-01-8 6,7-dimethyl-4-(3-(trifluoromethyl)phenyl)-8-pyrrolo<1,2-a>pyrimidine carbonitrile 
• 72851-20-8 7-(α,α,α-trifluoro-m-tolyl)-pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 72851-46-8 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester 
• 170960-00-6 3-carboethoxy-2-methyl-5-(3-trifluoromethylphenyl)pyrrolo<3,2-b>pyridine 
• 170960-01-7 3-(carbo-t-butoxy)-2-methyl-5-(3-trifluoromethylphenyl)pyrrolo<3,2-b>pyridine 
• 663608-26-2 2,4-di(tert-butyl)-6-[6-[3-(trifluoromethyl)phenyl]pyridin-2-yl]phenol 
• 1026365-36-5 7-(3-Trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride 
• 159223-93-5 7-(3-(trifluoromethyl)phenyl)-3-pyrazolol<1,5-a>pyrimidine carboxamidoxime 
• 159224-08-5 N-Hydroxy-6,7-dimethyl-4-(3-trifluoromethyl-phenyl)-pyrrolo[1,2-a]pyrimidine-8-carboxamidine 

Relevant articles and documents

Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors

We report here a thorough structure-activity relationship (SAR) with piperazinylureido sulfamates as inhibitors of human (h) carbonic anhydrase (CA, EC 4.2.1.1). A SAR investigation over the structure of reported anti-cancer zinc-binder CAIs such as SLC-0

6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: Formula (I) where: R6 is selected from the group consisting of (a, b, c, d, e) and other substituents are as defined in the specification.

COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE

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