72874-42-1

Basic information

• Product Name: 8-bromo-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
• Synonyms: 8-bromo-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
• CAS NO: 72874-42-1
• Molecular Weight: 396.289
• Mol File: 72874-42-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-bromo-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-bromo-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine(72874-42-1)
• EPA Substance Registry System: 8-bromo-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine(72874-42-1)

Safety Data

• Hazardous Substances Data: 72874-42-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 55-85-6 N-amino-2-(dimethylamino)acetamide 
• 34099-70-2 7-bromo-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione 

Relevant articles and documents

1-(Aminoalkyl)-6-aryl;-4H-s-triazole[4,3-a][1,4]benzodiazepines with antianxiety and antidepressant activity

A series of 1-(Aminoalkyl)-6-aryl;-4H-s-triazole[4,3-a][1,4]benzodiazepines has been prepared and evaluated for central nervous system activity. The authors have found that members of this series have activity in pharmacological test systems designed to detect both anxiolytic and antidepressant activity. Each type of activity could be varied independently by appropriate substituent selections.

Process for the production of 1-aminomethyl-6-phenyl-4h-s-triazolo-[4,3-a][1]benzodiazepines and intermediates

A multistep process for the production of a compound of the formula V: SPC1 wherein R' and R" are alkyl of 1 to 3 carbon atoms, inclusive or together EQU1 is pyrrolidino, piperidino, 4-methylpiperazino or morpholino; and wherein the rings A and B are unsubstituted, or substituted by one or more substituents selected from the group consisting of fluoro, chloro, bromo, nitro and trifluoromethyl, which comprises treating an equivalent of a compound of formula 1: SPC2 Wherein rings A and B are defined as above, with 2 equivalents of an α-phthalimido acetyl halide in an inert organic solvent to obtain a 1,3-dioxo-2-isoindolineacetic acid, [[N-(2-benzoylphenyl)-1,3-dioxo-2-isoindolineacetamido]methylene]hydrazide II which when treated with trifluoroacetic acid gives compound III; treating compound III with a dialkylmethyleneammonium chloride in an inert organic solvent to obtain a 2-[3-(dialkylamino)methyl-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone IV and treating IV with hydrazine in an alkanol to obtain a compound V above. Also claimed are the intermediates II and IV. The 1-aminomethyltriazolobenzodiazepine compounds (V) are used for treatment of anxieties and/or depressions in mammals and birds.