728919-99-1Relevant articles and documents
Anodic Oxidation of Aminotetrazoles: A Mild and Safe Route to Isocyanides
Leech, Matthew C.,Petti, Alessia,Tanbouza, Nour,Mastrodonato, Andrea,Goodall, Iain C. A.,Ollevier, Thierry,Dobbs, Adrian P.,Lam, Kevin
, p. 9371 - 9375 (2021/12/09)
A new electrochemical method for the preparation of isocyanides from easily accessible aminotetrazole derivatives has been developed, which tolerates an unprecedented range of functional groups. The use of chemical, rather than electrochemical, oxidation to afford isocyanides was also demonstrated, which provides access to these compounds for those without electrosynthesis equipment. The practicality of scale-up using flow electrochemistry has been demonstrated, in addition to the possibility of using electrochemically generated isocyanides in further reactions.
Isocyanide-based multicomponent reaction 'without' isocyanides
El Kaim, Laurent,Grimaud, Laurence,Schiltz, Aurélie
experimental part, p. 1401 - 1404 (2009/10/19)
We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a U
A convenient method for the preparation of benzyl isocyanides
Kitano, Yoshikazu,Manoda, Tetsuya,Miura, Teppei,Chiba, Kazuhiro,Tada, Masahiro
, p. 405 - 410 (2007/10/03)
Treatment of benzyl halides with silver salts (AgClO4, AgBF 4, or AgOTf) and trimethylsilyl cyanide (TMSCN) in CH 2Cl2 followed by cleavage of the carbon-silicon bond with aqueous NaHCO3 or TBAF directly afforded the corresponding isocyanides. Georg Thieme Verlag Stuttgart.