72912-99-3Relevant articles and documents
Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
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, (2015/09/22)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
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, (2012/04/23)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
A Synthesis of 5-Amino- and 5-Hydroxy-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids and Their Derivatives
Tamura, Yasumitsu,Fujita, Masanobu,Chen, Ling Ching,Ueno, Kyoji,Kita, Yasuyuki
, p. 289 - 296 (2007/10/02)
The synthesis and antimicrobial activity of 5-amino- and 5-hydroxy-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives have been investigated.The 5-hydroxy-3-quinolinecarboxylic acids were prepared by thermal cyclization of 3-oxocyclohexenylaminomethylenemalonates followed by aromatization with iodine-etahnol, ethylation and hydrolysis of products.The 5-amino derivatives were prepared by several steps involving novel aromatization of isoxazole intermediates.
