72936-34-6

Basic information

• Product Name: ethyl 2-nitro-2-phenylacetate
• Synonyms: ethyl 2-nitro-2-phenylacetate
• CAS NO: 72936-34-6
• Molecular Weight: 209.202
• Mol File: 72936-34-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 92 °C(Press: 0.15 Torr)
• Density: 1.214±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ethyl 2-nitro-2-phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-nitro-2-phenylacetate(72936-34-6)
• EPA Substance Registry System: ethyl 2-nitro-2-phenylacetate(72936-34-6)

Safety Data

• Hazardous Substances Data: 72936-34-6(Hazardous Substances Data)

Upstream product

• 626-35-7 nitroacetic acid ethyl ester 
• 108-86-1 bromobenzene 
• 19078-72-9 bromo(phenyl)acetyl chloride 
• 4870-65-9 2-bromophenylacetic acid 
• 7697-37-2 nitric acid 
• 101-97-3 Ethyl 2-phenylethanoate 
• 64-17-5 ethanol 
• 108085-99-0 2-(α-nitrobenzyl)-4,4-dimethyl-2-oxazoline 
• 622-42-4 1-nitro-1-phenylmethane 
• 105-58-8 Diethyl carbonate 
• 40561-27-1 1-cyano-1-methylethylnitrate 
• 83-13-6 diethyl 2-phenylmalonate 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 

Downstream Products

• 93-89-0 benzoic acid ethyl ester 
• 101-97-3 Ethyl 2-phenylethanoate 
• 6097-58-1 ethyl 2-phenyl-2-aminoacetate 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 622-42-4 1-nitro-1-phenylmethane 
• 92976-14-2 hydroxyimino-(2-nitro-phenyl)-acetic acid 
• 885590-32-9 1-oxy-2-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester 
• 1009296-78-9 2-nitro-5-oxo-2-phenyl-pentanoic acid ethyl ester 
• 72936-47-1 Hydroxyamino-phenyl-acetic acid ethyl ester 
• 57764-48-4 hydroxyimino-(2-nitro-phenyl)-acetic acid ethyl ester 

Relevant articles and documents

Enantioselective Addition of α-Nitroesters to Alkynes

By using Rh–H catalysis, we couple α-nitroesters and alkynes to prepare α-amino-acid precursors. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alkyne undergoes isomerization to generate a RhIII–π-allyl electrophile, which is trapped by an α-nitroester nucleophile. A subsequent reduction with In powder transforms the allylic α-nitroesters to the corresponding α,α-disubstituted α-amino esters.

Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives

In order to develop spin traps with an optimal ratio between hydrophilic and lipophilic properties, low toxicity, and high stability of spin adducts (especially with superoxide radicals), several EMPO-derived spin traps have recently been synthesized forming more stable superoxide adducts (t1/2 > 20 min) than DMPO or DEPMPO. In this study, ESR-, 1H-, and 13C-NMR data of several phenyl- or n-pentyl-substituted EMPO derivatives are presented with full signal assignment. Methyl groups at position 3 or 4 stabilized the superoxide adducts considerably. Spin adducts from other oxygen- and carbon-centered radicals (e.g., derived from methanol or linoleic acid hydroperoxide) are also described.