72942-62-2

Basic information

• Product Name: 2-Benzoyl-4-methylphenyloxyacetic acid ethyl ester
• Synonyms: 2-Benzoyl-4-methylphenyloxyacetic acid ethyl ester
• CAS NO: 72942-62-2
• Molecular Formula: C₁₈H₁₈O₄
• Molecular Weight: 298.33
• Mol File: 72942-62-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 457.3 °C at 760 mmHg
• Flash Point: 202.1 °C
• Appearance: /
• Density: 1.143 g/cm³
• Vapor Pressure: 1.51E-08mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 2-Benzoyl-4-methylphenyloxyacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzoyl-4-methylphenyloxyacetic acid ethyl ester(72942-62-2)
• EPA Substance Registry System: 2-Benzoyl-4-methylphenyloxyacetic acid ethyl ester(72942-62-2)

Safety Data

• Hazardous Substances Data: 72942-62-2(Hazardous Substances Data)

Usage

General Description

2-Benzoyl-4-methylphenyloxyacetic acid ethyl ester is a chemical compound with a complex and specific structure. It is an ethyl ester derivative of 2-benzoyl-4-methylphenyloxyacetic acid, containing a benzoyl group, a methyl group, and an ethyl ester group. 2-Benzoyl-4-methylphenyloxyacetic acid ethyl ester is commonly used in organic synthesis and pharmaceutical research as a reagent or intermediate for the production of various pharmaceuticals and organic compounds. It may also have potential applications in the field of medicinal chemistry due to its unique structure and properties. However, further research and studies are needed to fully understand its potential uses and effects.

InChI:InChI=1/C18H18O4/c1-3-21-17(19)12-22-16-10-9-13(2)11-15(16)18(20)14-7-5-4-6-8-14/h4-11H,3,12H2,1-2H3

Upstream product

• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 105-39-5 chloroacetic acid ethyl ester 
• 98-88-4 benzoyl chloride 
• 614-34-6 p-cresyl benzoate 
• 106-44-5 p-cresol 

Downstream Products

• 871835-38-0 (2-benzoyl-4-methyl-phenoxy)-acetic acid 
• 807643-20-5 2-[2-benzoyl-4-methylphenoxy]acetohydrazide 
• 1578261-62-7 ethyl (N'-{2-[2-benzoyl-4-methylphenoxy]acetyl}hydrazinocarbonyl)acetate 
• 1630042-90-8 2-(2-benzoyl-4-methylphenoxy)methyl-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis, analgesic, anti-inflammatory, COX/5-LOX inhibition, ulcerogenic evaluation, and docking study of benzimidazole bearing indole and benzophenone analogs

Inflammation therapy is particularly focused on the development of safer non-steroidal anti-inflammatory drugs (NSAIDs), administered to control inflammation. It is typically considered that dual-inhibition of COX/5-LOX, which improves efficacy and has fewer side effects, is an effective technique for combating inflammation. In this perspective, the series of titled compounds (10a-j) were designed, synthesized, and characterized following with the anti-inflammatory, analgesic, and ulcerogenic evaluation. The investigation of the potentiality of the titled compounds (10a-j) displayed a high degree of anti-inflammatory activity. The compounds displaying potential analgesic activity were identified and validated further for evaluation of analgesic, anti-inflammatory activity, and subsequent ulcerogenic evaluation. In addition, the COX-1, COX-2, and 5-LOX analyses were carried out in vitro. Among (10a-j) series, compound 10c with para substitution of fluoro group on the benzoyl ring and two chloro groups at ortho position in phenyl ring of benzophenone was observed to have good inhibitory potency. Furthermore, the in silico docking study was performed by using AutoDock tools docking software.

Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles

Synthetic pathway of the ten novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4- oxadiazoles as new potential antimicrobial agents is illustrated. Intramolecular cyclization of 2-(2-aroylaryloxy) aceto hydrazides to 2-[2-(aroyl)aroyloxy] methyl-1,3,4-oxadiazoles was