72985-20-7

Basic information

• Product Name: Benzoic acid, 2-(bromomethyl)-5-methyl-
• CAS NO: 72985-20-7
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.07100
• Mol File: 72985-20-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(bromomethyl)-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(bromomethyl)-5-methyl-(72985-20-7)
• EPA Substance Registry System: Benzoic acid, 2-(bromomethyl)-5-methyl-(72985-20-7)

Safety Data

• Hazardous Substances Data: 72985-20-7(Hazardous Substances Data)

Upstream product

• 610-72-0 2,5-dimethylbenzoic acid 

Downstream Products

• 848498-20-4 2-bromomethyl-5-methylbenzoic acid methyl ester 
• 72985-23-0 6-methylisobenzofuran-1(3H)-one 
• 72985-22-9 2-(hydroxymethyl)-5-methylbenzoic acid 

Relevant articles and documents

Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to β-amyloid fibrils

Based on the structural features of Indoprofen and PIB, a series of isoindol-1,3-diones 1a-k and isoindol-1-ones 2a-l were designed and synthesized. These 23 compounds were evaluated by competitive binding assay against aggregated Aβ42 fibrils using [125I]TZDM. All the isoindolone derivatives showed very good binding affinities with Ki values in the subnanomolar range (0.42-0.94 nM). Among them, isoindol-1,3-diones 1i and 1k and isoindol-1-ones 2c and 2i exhibited excellent binding affinities (Ki = 0.42-0.44 and 0.46-0.49 nM) than those of Indoprofen (Ki = 0.52 nM) and PIB (Ki = 0.70 nM). These results suggest that isoindolones could be served as a scaffold for potential AD diagnostic probes to monitor Aβ fibrils.

Microbial Stereodifferentiating Reduction of (+/-)4-Methyl- and (+/-)-6-Methyl-1-oxometacyclophanes and Revision of the Absolute Configuration of 4-Substituted Metacyclophanes

Partial oxidative hydrolysis of 4-bromo-1,1,10,10-bis(trimethylenedithio)metacyclophane (7) yielded the bromo ketones 8 and 9 which were respectively converted into (+/-)-4-methyl- (3) and (+/-)-6-methyl-1-oxometacyclophanes (4).The unambiguous synthesis of (+/-)-3 from 2,5-dimethylbenzoic acid (18) assigned their structures.Incubation of (+/-)-3 with Rhodotorula rubra gave a mixture of (-)-ketone 3, (-) axial alcohol 38, and (-) equatorial alcohol 39.The observed (-) Cotton effect indicated the pS configuration of (-)-3, and transformation of (-)-3 into (+)-4-methylmetacyclophane (5) permitted the assignment of the pR configuration to (+)-5, opposite to Schloegl's proposal.This conclusion was further supported by the parallel sequence of the steps starting from (+/-)-6-methyl ketone.