73-09-6

Basic information

• Product Name: Etozolin
• Synonyms: Etozolin;[3-Methyl-4-oxo-5-(1-piperidinyl)thiazolidin-2-ylidene]acetic acid ethyl;[3-Methyl-4-oxo-5-(1-piperidinyl)thiazolidin-2-ylidene]acetic acid ethyl ester;Elkapin;Etozoline;W-2900A
• CAS NO: 73-09-6
• Molecular Formula: C₁₃H₂₀N₂O₃S
• Molecular Weight: 284.378
• EINECS: 200-794-0
• Mol File: 73-09-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 140°
• Boiling Point: 230.9°C (rough estimate)
• Flash Point: 225.6°C
• Appearance: /
• Density: 1.2117 (rough estimate)
• Vapor Pressure: 2.86E-08mmHg at 25°C
• Refractive Index: 1.6360 (estimate)
• CAS DataBase Reference: Etozolin(CAS DataBase Reference)
• NIST Chemistry Reference: Etozolin(73-09-6)
• EPA Substance Registry System: Etozolin(73-09-6)

Safety Data

• Hazardous Substances Data: 73-09-6(Hazardous Substances Data)

Usage

Originator

Elkapin,Goedecke,W. Germany,1977

Manufacturing Process

To a stirred solution of 20 g (0.1 mol) 2-carbethoxymethylene-3-methyl-4- thiazolidinone in 120 ml chloroform is added, dropwise, a solution of 5 ml (0.1 mol) bromine in 20 ml chloroform. The solvent is removed by distillation and the residue crystallized from methanol to yield 18 g (65%) of 2- carbethoxymethylen-3-methyl-5-bromo-4-thiazolidinone, MP 76°C.To a solution of 28 g (0.1 mol) 2-carbethoxymethylene-3-methyl-5-bromo-4- thiazolidinone prepared as described in 200 ml benzene is added (0.2 mol) piperidine and the mixture is allowed to stand for 3 hours at 25°C. The resulting suspension is filtered to remove the precipitated piperidine hydrobromide and the filtrate is evaporated to dryness. The residue is taken up in ether, filtered and the filtrate saturated with dry hydrogen chloride to yield the hydrochloride salt of 2-carbethoxymethylene-3-methyl-5-piperidino- 4-thiazolidinone, MP 158°C to 159°C.

Therapeutic Function

Diuretic

InChI:InChI=1/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9+

Upstream product

• 110-89-4 piperidine 
• 86379-70-6 (5-bromo-3-methyl-4-oxo-thiazolidin-2-ylidene)-acetic acid ethyl ester 
• 24146-36-9 2-ethoxycarbonylmethylidene-4,5-dihydro-4-thiazolinone 
• 27653-75-4 (3-methyl-4-oxo-thiazolidin-2-ylidene)-acetic acid ethyl ester 

Downstream Products

• 56784-39-5 ozolinone 

Relevant articles and documents

Combination of two active substances

The invention concerns the use of a compound with diuretic properties and of a magnesium supplementation in the form of magnesium monoaspartate hydrochloride, magnesium oxide, magnesium hydroxide or magnesium carbonate, and optionally of a potassium supplementation, and pharmaceutical preparations comprising a compound with diuretic properties and a magnesium supplementation in the form of magnesium monoasparate hydrochloride, magnesium oxide, magnesium hydroxide, or magnesium carbonate and optionally a potassium supplementation.