73033-72-4Relevant articles and documents
Michael Additions to Steroidal Enones
Campbell, Malcolm M.,Jigajinni, Veerappa B.,Wightman, Richard H.
, p. 2537 - 2546 (2007/10/02)
Reaction of steroidal 1-en-3-ones with electron-rich arene thiols gives 1α-adducts under base catalysis, whilst with acid catalysis 1α,3-bis-adducts are formed.Interaction of thiourea with 1-en-3-one systems gives a novel bridged ring structure.Various related Michael additions are described, and parameters defined for successful reaction in steroidal enones.Oxidation of the β-arylthio ketones to the sulphoxide leads to spontaneous regeneration of the enone system.
