7311-68-4

Basic information

• Product Name: 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID, 98+%
• Synonyms: 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID, 98+%;4 5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID 97%;3,5-Dibromo-2-thiophenecarboxylic acid;3,5-Dibromothiophene-2-carboxylic acid;4,5-DibroMo-thiophen-2-carboxylic acid;2-Thiophenecarboxylic acid, 3,5-dibroMo-
• CAS NO: 7311-68-4
• Molecular Formula: C₅H₂Br₂O₂S
• Molecular Weight: 285.94118
• Mol File: 7311-68-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 215-220°C
• Boiling Point: 350.015 °C at 760 mmHg
• Flash Point: 165.484 °C
• Appearance: /
• Density: 2.309 g/cm³
• Storage Temp.: 2-8°C
• PKA: 2.90±0.10(Predicted)
• CAS DataBase Reference: 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID, 98+%(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID, 98+%(7311-68-4)
• EPA Substance Registry System: 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID, 98+%(7311-68-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 7311-68-4(Hazardous Substances Data)

Usage

General Description

4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID, 98+%, is a chemical compound with a high purity of at least 98%. It is a derivative of thiophene, which is a heterocyclic compound containing sulfur and carbon atoms in the ring. The presence of two bromine atoms in the 4 and 5 positions of the thiophene ring makes this compound useful in various chemical reactions and synthesis processes. It can be used as a building block in the production of pharmaceuticals, agrochemicals, and electronic materials. The high purity of this compound ensures its reliability and effectiveness in research and industrial applications.

Upstream product

• 3140-92-9 2,4-dibromothiophene 
• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 15719-64-9 methylammonium carbonate 
• 3141-24-0 2,3,5-tribromothiophene 
• 7311-64-0 3-bromothiophene-2-carboxylic acid 
• 124-38-9 carbon dioxide 
• 3141-27-3 2,5-dibromothiophen 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 

Downstream Products

• 58777-66-5 3,5-dibromo-thiophene-2-carbonyl chloride 
• 62224-21-9 3,5-dibromo-thiophene-2-carboxylic acid methyl ester 
• 62224-22-0 ethyl 3,5-dibromothiophene-2-carboxylate 
• 675872-43-2 2-(hydroxymethyl)-3,5-dibromothiophene 

Relevant articles and documents

Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/ dibromothiazoles and arylboronic acids. Synthesis of PPARβ/δ agonists

A reactivity study, aided by NMR spectroscopy, allowed a mechanistic rationale to be postulated for the palladium-catalyzed regioselective coupling of arylboronic acid (and arylstannane where feasible) at the position next to the sulfur atom in functional

Synthesis of Thieno--, -- and --thiophenes and Thieno--, -- and --thienopyrimidin-7(6H)-ones Starting from Thiophene

3-Bromo-, 3,5-dibromo- and 3,4,5-tribromo-2-thienyllithium have been prepared by bromine ->lithium exchange and converted into a number of thiophene derivatives, including the corresponding 2-carbaldehydes.The aldehydes have been converted into the corresponding thiophene-2-carbonitriles.Metallation of 2,5-dibromo- or 2,4,5-tribromo-thiophene with LDA occured at a vacant 3-position but the resulting 3-lithiated thiophenes rearranged (mechanism discussed) to 3,5-dibromo- and 3,4,5-tribromo-2-thienyllithium, which were quenched with various electrophiles.Attempts to dilithiate 2,5-dibromothiophene with LDA were unsuccessful. 3,4-Dibromo-2,5-dilithiothiophene was prepared from 2,3,4,5-tetrabromothiophene but it failed to yield the 2,5-dicarbaldehyde with N,N-dimethylformamide.The title thienothiophenes were prepared by reaction of a 3-bromothiophene-2-carbaldehyde, a 2-bromothiophene-3-carbaldehyde (prepared by bromination of a thiophene-3-carbaldehyde) or a 4-bromothiophene-3-carbaldehyde, or a corresponding nitrile, with ethyl 2-sulfanylacetate or 2-sulfanylacetamide.Thienothiophenes carrying an o-aminocarboxamide substitution pattern gave the title thienothienopyrimidinones with triethyl orthoformate.