7315-66-4

Basic information

• Product Name: diethyl 2-(1-oxo-1-phenylpropan-2-yl)malonate
• Synonyms: diethyl 2-(1-oxo-1-phenylpropan-2-yl)malonate
• CAS NO: 7315-66-4
• Molecular Weight: 292.332
• Mol File: 7315-66-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: diethyl 2-(1-oxo-1-phenylpropan-2-yl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-(1-oxo-1-phenylpropan-2-yl)malonate(7315-66-4)
• EPA Substance Registry System: diethyl 2-(1-oxo-1-phenylpropan-2-yl)malonate(7315-66-4)

Safety Data

• Hazardous Substances Data: 7315-66-4(Hazardous Substances Data)

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 105-53-3 diethyl malonate 
• 1462-12-0 diethyl ethylidenemalonate 
• 65-85-0 benzoic acid 
• 611-73-4 Benzoylformic acid 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 

Downstream Products

• 7315-67-5 3-methyl-4-oxo-4-phenylbutanoic acid 
• 52240-29-6 (1-methyl-2-oxo-2-phenyl-ethyl)-malonic acid 
• 7315-68-6 3-methyl-4-phenylbutanoic acid 
• 7315-69-7 3-methyl-4-phenyl-butyryl chloride 
• 7315-71-1 6-Benzyl-2-methyl-heptanol-⁽⁴⁾ 
• 7315-70-0 6-Benzyl-2-methyl-heptanon-⁽⁴⁾ 

Relevant articles and documents

Decarboxylative 1,4-Addition of α-Oxocarboxylic Acids with Michael Acceptors Enabled by Photoredox Catalysis

Enabled by iridium photoredox catalysis, 2-oxo-2-(hetero)arylacetic acids were decarboxylatively added to various Michael acceptors including α,β-unsaturated ester, ketone, amide, aldehyde, nitrile, and sulfone at room temperature. The reaction presents a new type of acyl Michael addition using stable and easily accessible carboxylic acid to formally generate acyl anion through photoredox-catalyzed radical decarboxylation.

Cu(OAc)2-Triggered Cascade Reaction of Malonate-Tethered Acyl Oximes with Indoles, Indole-2-alcohols, and Indole-2-carboxamides

A Cu(OAc)2-promoted cascade reaction of malonate-tetherd acyl oximes with indoles, indole-2-alcohols, or indole-2-carboxmides provides facile access to polysubstituted 3-pyrrolin-2-ones. The reaction features the generation of two adjacent elec

Decarboxylative Giese-Type Reaction of Carboxylic Acids Promoted by Visible Light: A Sustainable and Photoredox-Neutral Protocol

We describe herein a transition-metal-free method for the decarboxylative generation of radicals from carboxylic acids and their 1,4-addition to Michael acceptors. The Fukuzumi catalyst (9-mesitylene-10-methylacridinium perchlorate, [Acr-Mes]ClO4) enabled this transformation under visible-light irradiation at room temperature with CO2 as the only byproduct. The scope and limitations of this protocol were examined by using a range of Michael acceptors (15 examples) and carboxylic acids (18 examples). The use of 3-hydroxypivalic acid in this protocol allowed the straightforward formation of a diastereomerically pure δ-lactone. Moreover, when a homoallylic acid was used, a radical cascade reaction took place with the formation of three C–C bonds.