73177-36-3Relevant articles and documents
Transaminase-Mediated Amine Borrowing via Shuttle Biocatalysis
Taday, Freya,Ryan, James,O’Sullivan, Rachel,O’Reilly, Elaine
supporting information, p. 74 - 79 (2022/01/04)
Shuttle catalysis has emerged as a useful methodology for the reversible transfer of small functional groups, such as CO and HCN, and goes far beyond transfer hydrogenation chemistry. While a biocatalytic hydrogen-borrowing methodology is well established, the biocatalytic borrowing of alternative functional groups has not yet been realized. Herein, we present a new concept of amine borrowing via biocatalytic shuttle catalysis, which has no counterpart in chemo-shuttle catalysis and allows efficient intermolecular amine shuttling to generate reactive intermediates in situ. By coupling this dynamic exchange with an irreversible downstream step to displace the reaction equilibrium in the forward direction, high conversion to target products can be achieved. We showcase the potential of this amine-borrowing methodology using a biocatalytic equivalent of both the Knorr-pyrrole synthesis and Pictet-Spengler reaction.
Zheda-phos for general α-monoarylation of acetone with aryl chlorides
Li, Pengbin,Lue, Bo,Fu, Chunling,Ma, Shengming
supporting information, p. 1255 - 1259 (2013/06/27)
A new, readily available, and air-stable monophosphine ligand, i.e., Zheda-Phos, has been developed for the general and highly effective palladium-catalyzed monoarylation of acetone with aryl chlorides. The reaction rate is of first-order dependence with the aryl chloride. Copyright
