73232-47-0 Usage
Description
(5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propynyl)morphinan-6-one is a chemical compound belonging to the morphinan class of alkaloids, derived from morphine. It is recognized for its potent analgesic and narcotic properties, acting as an agonist at the mu-opioid receptor in the central nervous system, which contributes to its pain-relieving effects. (5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propynyl)morphinan-6-one also possesses sedative and antitussive properties, making it beneficial for the treatment of cough and other respiratory conditions. However, its potential for abuse and addiction has led to its classification as a controlled substance, available only by prescription.
Uses
Used in Pharmaceutical Industry:
(5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propynyl)morphinan-6-one is used as a potent analgesic for the treatment of severe pain. Its high efficacy in pain relief is attributed to its action as a mu-opioid receptor agonist, which helps alleviate pain by binding to these receptors in the central nervous system.
Used in Narcotic Applications:
(5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propynyl)morphinan-6-one is also used as a narcotic due to its ability to induce feelings of euphoria and relaxation. Its sedative properties make it useful in managing anxiety and stress-related conditions. However, its use is strictly regulated due to the risk of abuse and addiction.
Used in Respiratory Treatments:
(5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propynyl)morphinan-6-one is used as an antitussive agent in the treatment of cough and other respiratory conditions. Its ability to suppress cough reflexes makes it a valuable component in medications aimed at providing relief from respiratory discomfort.
Check Digit Verification of cas no
The CAS Registry Mumber 73232-47-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,2,3 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 73232-47:
(7*7)+(6*3)+(5*2)+(4*3)+(3*2)+(2*4)+(1*7)=110
110 % 10 = 0
So 73232-47-0 is a valid CAS Registry Number.
73232-47-0Relevant articles and documents
Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain
Grinnell, Steven G.,Uprety, Rajendra,Varadi, Andras,Subrath, Joan,Hunkele, Amanda,Pan, Ying Xian,Pasternak, Gavril W.,Majumdar, Susruta
, p. 977 - 993 (2020/05/29)
Mu opioid receptors (MOR-1) mediate the biological actions of clinically used opioids such as morphine, oxycodone, and fentanyl. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, generating multiple splice variants. One type of splice variants are truncated variants containing only six transmembrane domains (6TM) that mediate the analgesic action of novel opioid drugs such as 3′-iodobenzoylnaltrexamide (IBNtxA). Previously, we have shown that IBNtxA is a potent analgesic effective in a spectrum of pain models but lacks many side-effects associated with traditional opiates. In order to investigate the targets labeled by IBNtxA, we synthesized two arylazido analogs of IBNtxA that allow photolabeling of mouse mu opioid receptors (mMOR-1) in transfected cell lines and mMOR-1 protein complexes that may comprise the 6TM sites in mouse brain. We demonstrate that both allyl and alkyne arylazido derivatives of IBNtxA efficiently radio-photolabeled mMOR-1 in cell lines and MOR-1 protein complexes expressed either exogenously or endogenously, as well as found in mouse brain. In future, design and application of such radio-photolabeling ligands with a conjugated handle will provide useful tools for further isolating or purifying MOR-1 to investigate site specific ligand–protein contacts and its signaling complexes.
N-OXIDES OF 4,5-EPOXY-MORPHINANIUM ANALOGS
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Page/Page column 110, (2008/12/06)
Novel N-oxides of 4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the N-oxides of 4,5-epoxy-morphinanium analogs and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.
