73298-54-1

Basic information

• Product Name: CALMODULIN
• Synonyms: 1,1-CYCLOHEXANEDIACETIC ACID DIAMIDE;PHOSPHODIESTERASE 3,5'-CYCLIC-NUCLEOTIDE ACTIVATOR;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE-ACTIVATOR;PHOSPHODIESTERASE 3'5'-CYCLIC NUCLEOTIDE-ACTIVATOR;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE ACTIVATOR BOVINE;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE ACTIVATOR (HUMAN);Calmodulin (ox brain);CaM, Phosphodiesterase 3μ,5μ-cyclic nucleotide activator from bovine brain
• CAS NO: 73298-54-1
• Molecular Formula: C10H18N4O4
• Molecular Weight: 258.27432
• EINECS: 277-370-7
• Mol File: 73298-54-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• CAS DataBase Reference: CALMODULIN(CAS DataBase Reference)
• NIST Chemistry Reference: CALMODULIN(73298-54-1)
• EPA Substance Registry System: CALMODULIN(73298-54-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 73298-54-1(Hazardous Substances Data)

Usage

Description

Calmodulin (CaM), also known as a highly conserved Ca2+-binding protein, is a small protein that is abundantly present in the brain and coded by three genes (CALM1-3). It plays a crucial role in various cellular processes by binding to target proteins in response to changes in intracellular calcium levels.

Uses

Used in Research Applications:
Calmodulin is used as a research tool for studying its role in various cellular processes. The Anti-Calmodulin antibody is employed to detect endogenous levels of total Calmodulin protein, which helps in understanding its function and interaction with other proteins.
Used in Western Blotting:
Calmodulin is used as a target protein in Western blotting, a widely used technique for detecting and analyzing specific proteins in a sample. This application aids in the identification and quantification of Calmodulin in various experimental setups.
Used in In Vitro Phosphorylation Assays:
Calmodulin is used as a component in in vitro phosphorylation assays, specifically for the recombinant retinoic acid-inducible gene I protein. This application helps in understanding the phosphorylation events and their impact on protein function.
Used in Proteolysis and Deamidation Studies:
Calmodulin bovine has been utilized in endoprotease Glu-C proteolysis and deamidation studies. These applications provide insights into the structural and functional aspects of Calmodulin and its role in various biological processes.
Used in Pharmaceutical Applications:
Calmodulin is used as a target for the development of drugs that modulate its activity. This can have potential therapeutic applications in treating diseases associated with the dysregulation of calcium signaling and Calmodulin function.
Used in Diagnostic Applications:
Calmodulin can be used as a biomarker in diagnostic applications, helping in the detection and monitoring of certain diseases or conditions related to its dysregulation.

Biochem/physiol Actions

Calmodulin (CaM) possesses Ca2+-dependent modulatory roles. It participates in cell proliferation and muscle activity. Calmodulin plays a major role in catecholaminergic polymorphic ventricular tachycardia (CPVT) and in long QT syndrome (LQTS). This protein modulates the transcriptional processes required for proper heart function.