73332-79-3

Basic information

• Product Name: 2-Methyl-5-nitro-2,3-dihydro-imidazo[2,1-b]oxazole
• Synonyms: 2-Methyl-5-nitro-2,3-dihydro-imidazo[2,1-b]oxazole;AIDS-059076
• CAS NO: 73332-79-3
• Molecular Formula: C6H7N3O3
• Molecular Weight: 169.13808
• Mol File: 73332-79-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 333.7°C at 760 mmHg
• Flash Point: 155.6°C
• Appearance: /
• Density: 1.71g/cm³
• Vapor Pressure: 0.000135mmHg at 25°C
• Refractive Index: 1.72
• CAS DataBase Reference: 2-Methyl-5-nitro-2,3-dihydro-imidazo[2,1-b]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-5-nitro-2,3-dihydro-imidazo[2,1-b]oxazole(73332-79-3)
• EPA Substance Registry System: 2-Methyl-5-nitro-2,3-dihydro-imidazo[2,1-b]oxazole(73332-79-3)

Safety Data

• Hazardous Substances Data: 73332-79-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H7N3O3/c1-4-3-8-5(9(10)11)2-7-6(8)12-4/h2,4H,3H2,1H3

Upstream product

• 5213-49-0 2,4-dinitro-1H-imidazole 
• 75-56-9 methyloxirane 
• 57531-37-0 2-chloro-4-nitro-1H-imidazole 

Relevant articles and documents

Nitroimidazoles XXI 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles with antitubercular activity

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Potential Radiosensitizing Agents. 2. Synthesis and Biological Activity of Derivatives of Dinitroimidazole with Oxiranes

A series of 1-substituted 2,4-dinitroimidazole analogues have been synthesized and tested for their radiosensitizing ability for selectively sensitizing hypoxic mammalian cells to the lethal effect of radiation.The reaction of 2,4(5)-dinitroimidazole (1) with a variety of oxiranes upon heating in absolute ethanol yielded the expected 1-substituted 2,4-dinitroimidazoles (2) and also resulted in the formation of a novel class of isomeric nitroimidazooxazoles (3 and 4) by intramolecular cyclization.The results of radiosensitizing activity of these agents against hypoxic Chinese hamster cells (V-79) indicated that 2,4-dinitroimidazoles were better sensitizers than the nitroimidazooxazoles, suggesting the necessity of the 2-nitro function in the molecule.The 1-(2-hydroxy-3-methoxypropyl)-2,4-dinitroimidazole (2d) was found to be the most effective radiosensitizer of this series.