733742-56-8

Basic information

• Product Name: (S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-ureido]-3-methyl-butyric acid methyl ester
• CAS NO: 733742-56-8
• Molecular Weight: 527.661
• Mol File: 733742-56-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-ureido]-3-methyl-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-ureido]-3-methyl-butyric acid methyl ester(733742-56-8)
• EPA Substance Registry System: (S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-ureido]-3-methyl-butyric acid methyl ester(733742-56-8)

Safety Data

• Hazardous Substances Data: 733742-56-8(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 30293-86-8 methyl (S)-(-)-2-isocyanato-3-methylbutyrate 
• 162536-41-6 (2R,3S)-1-(benzylamino)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol 

Relevant articles and documents

Probing pockets S2-S4′ of the γ-secretase active site with (hydroxyethyl)urea peptidomimetics

(Hydroxyethyl)urea peptidomimetics are potent inhibitors of γ-secretase that are accessible in a few synthetic steps. Systematic alteration of P2-P4′ revealed that the corresponding S2-S4′ active site pockets accommodate a variety of substituents, consistent with the fact that this protease cleaves a variety of single-pass membrane proteins; however, phenylalanine is not well tolerated at P2′. A compound spanning P2-P3′ was identified as a low nM inhibitor of γ-secretase activity both in cells and under cell-free conditions.