733750-99-7 Usage
General Description
AR 231453 is a chemical compound with the molecular formula C17H16N4O and a molecular weight of 292.3 g/mol. It is a selective serotonin receptor antagonist and has been studied for its potential use in the treatment of various psychiatric disorders, including anxiety and depression. AR 231453 acts as an antagonist at the 5-HT2C receptor and has been shown to have anxiolytic and antidepressant effects in animal studies. While the exact mechanism of action is not fully understood, AR 231453 shows promise as a potential therapeutic agent for the management of mood and anxiety disorders. However, further research is needed to fully elucidate its pharmacological properties and potential clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 733750-99-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,3,7,5 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 733750-99:
(8*7)+(7*3)+(6*3)+(5*7)+(4*5)+(3*0)+(2*9)+(1*9)=177
177 % 10 = 7
So 733750-99-7 is a valid CAS Registry Number.
733750-99-7Relevant articles and documents
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119
Semple, Graeme,Fioravanti, Beatriz,Pereira, Guillherme,Calderon, Imelda,Uy, Jane,Choi, Karoline,Xiong, Yifeng,Ren, Albert,Morgan, Michael,Dave, Vibha,Thomsen, William,Unett, David J.,Xing, Charles,Bossie, Stuart,Carroll, Chris,Chu, Zhi-Liang,Grottick, Andrew J.,Hauser, Erin K.,Leonard, James,Jones, Robert M.
supporting information; experimental part, p. 5172 - 5175 (2009/07/01)
GPR119 is a rhodopsin-like GPCR expressed in pancreatic β-cells and incretin releasing cells in the GI tract. As with incretins, GPR119 increases cAMP levels in these cell types, thus making it a highly attractive potential target for the treatment of dia
