73385-91-8 Usage
Description
N-(tert-butoxycarbonyl)-L-tyrosyl-D-methionylglycyl-4-nitro-3-phenyl-L-alanyl-L-prolinamide is a peptide chemical compound made up of amino acids tyrosine, methionine, glycine, alanine, and proline. It is commonly utilized in pharmaceutical research and as a biochemical tool for investigating the structure and function of proteins. The N-terminal t-butoxycarbonyl (Boc) group acts as a protective group that can be removed under acidic conditions, facilitating the synthesis and manipulation of the peptide. The inclusion of a nitro group in its structure may enhance its potential biological activity or pharmacological properties. This intricate chemical compound is a valuable asset for the study and development of new drugs and treatments.
Uses
Used in Pharmaceutical Research:
N-(tert-butoxycarbonyl)-L-tyrosyl-D-methionylglycyl-4-nitro-3-phenyl-L-alanyl-L-prolinamide is used as a research tool for studying protein structure and function, aiding in the development of new drugs and treatments.
Used in Biochemical Applications:
In the field of biochemistry, this compound is employed as a biochemical tool, enabling researchers to explore the intricacies of protein interactions and mechanisms.
Used in Drug Development:
N-(tert-butoxycarbonyl)-L-tyrosyl-D-methionylglycyl-4-nitro-3-phenyl-L-alanyl-L-prolinamide is used as a component in drug development, potentially contributing to the creation of novel pharmaceuticals with enhanced biological activity or pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 73385-91-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,3,8 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 73385-91:
(7*7)+(6*3)+(5*3)+(4*8)+(3*5)+(2*9)+(1*1)=148
148 % 10 = 8
So 73385-91-8 is a valid CAS Registry Number.
InChI:InChI=1/C35H47N7O10S/c1-20(38-22-9-7-6-8-10-22)30(45)28-26(42(50)51)19-41(29(28)31(36)46)27(44)18-37-32(47)24(15-16-53-5)39-33(48)25(40-34(49)52-35(2,3)4)17-21-11-13-23(43)14-12-21/h6-14,20,24-26,28-29,38,43H,15-19H2,1-5H3,(H2,36,46)(H,37,47)(H,39,48)(H,40,49)/t20-,24+,25-,26?,28?,29-/m0/s1
73385-91-8Relevant articles and documents
Peripherally acting enkephalin analogues. 1. Polar pentapeptides
Hardy,Lowe,Sang,Simpkin,Wilkinson,Follenfant,Smith
, p. 960 - 966 (2007/10/02)
The design, synthesis, and biological activity of a series of highly polar enkephalin-related pentapeptides are reported. These analogues incorporate structural features that exclude them from the central nervous system and thereby restrict their action to peripherally located receptors. Hydrophilic analogues were obtained by introduction of polar D-amino acid residues at position 2 and, in certain cases, by conversion of the N-terminal amino group of the Tyr residue to a guanidino function. The peptides were synthesized by classical solution methods. All compounds demonstrated in vitro opioid activity in the GPI and all were shown to possess antinociceptive activity in chemically induced writhing models. The analgesic effects were shown to be predominantly peripherally mediated by antagonism of antinociception with the peripheral antagonist N-methylnalorphine. Comparative data obtained in writhing and hot-plate tests were also supportive of a peripheral mode of action. Compound 13a, L-tyrosyl-D-arginylglycyl-L-4-nitrophenylalanyl-L-prolinamide (BW 443C), was identified as having a favorable pharmacological profile, indicating a high level of peripheral selectivity, and worthy of further investigation.
