73453-77-7

Basic information

• Product Name: 4,5-DIHYDRO-2-(3-METHOXYPHENYL)-4,4-DIMETHYLOXAZOLE
• Synonyms: 4,5-DIHYDRO-2-(3-METHOXYPHENYL)-4,4-DIMETHYLOXAZOLE
• CAS NO: 73453-77-7
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• Mol File: 73453-77-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-DIHYDRO-2-(3-METHOXYPHENYL)-4,4-DIMETHYLOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIHYDRO-2-(3-METHOXYPHENYL)-4,4-DIMETHYLOXAZOLE(73453-77-7)
• EPA Substance Registry System: 4,5-DIHYDRO-2-(3-METHOXYPHENYL)-4,4-DIMETHYLOXAZOLE(73453-77-7)

Safety Data

• Hazardous Substances Data: 73453-77-7(Hazardous Substances Data)

Upstream product

• 78265-39-1 N-(1,1-Dimethyl-2-hydroxyethyl)-3-methoxy-benzamid 
• 586-38-9 3-Methoxybenzoic acid 
• 1527-89-5 3-methoxybenzonitrile 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 229027-91-2 2-(2-Iodo-3-methoxyphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 1066-54-2 trimethylsilylacetylene 
• 1711-05-3 m-anisoyl chloride 
• 30093-99-3 4,4-dimethyl-2-oxazoline 
• 2398-37-0 3-methoxyphenyl bromide 

Downstream Products

• 107977-64-0 2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-6-methoxy-benzoic acid 
• 107977-68-4 C₁₂⁽¹³⁾CH₁₅NO₄ 
• 63478-14-8 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-6-methoxyaniline 
• 92592-41-1 1-(2-hydroxy-1,1-dimethylethylimino)-4-methoxy-3-phenyl-1,3-dihydro-2-benzofuran 
• 107977-84-4 2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-6-fluoro-benzoic acid methyl ester 
• 107977-65-1 2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-6-methoxy-benzoic acid methyl ester 
• 72623-17-7 2-(2-Methyl-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 76513-53-6 2-(3-Methoxy-4-methyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 139177-23-4 [2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-6-methoxy-phenyl]-methanol 
• 229027-91-2 2-(2-Iodo-3-methoxyphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 

Relevant articles and documents

Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines

A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, ethyl cyanoformate or allylic bromides (39 examples, 62–99 % yield) is reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50 °C, 4 h) provided the corresponding nitriles (36 examples, 73–99 % yield). Conversions of these nitriles to valuable heterocycles are reported, and a tentative mechanism is proposed.

CARBAMOYL-SUBSTITUTED SPIRO DERIVATIVE

A compound represented by, e.g. the formula (I): [wherein X, Y, Z, and W each independently represent optionally substituted methine; A, B, and D each independently represent -C(O)-, etc.; Q represents a methine or a nitrogen; and R represents the formula

A facile one stage synthesis of oxazolines under microwave irradiation

A rapid, high yielding procedure for the synthesis of 2-substituted oxazolines has been achieved under microwave irradiation from alkyl and aryl nitriles and β-amino alcohols using a mild Lewis acid catalyst.