7348-78-9Relevant articles and documents
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
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Paragraph 00815; 00816, (2021/11/26)
The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.
Visible Light-Mediated Photochemical Reactions of 2-(2′-Alkenyloxy)cycloalk-2-enones
Gra?l, Raphaela,Jandl, Christian,Bach, Thorsten
, p. 11426 - 11439 (2020/10/12)
The title compounds were prepared, and their reactivity was studied upon sensitized irradiation at λ = 420 nm. Thioxanthen-9-one was employed as the sensitizer at a loading of 10 mol % in small-scale reactions and of 2.5 mol % on a larger scale. Cyclohex-
Electrophilic rearrangements of chiral amides: A traceless asymmetric α-allylation
Peng, Bo,Geerdink, Danny,Maulide, Nuno
supporting information, p. 14968 - 14971 (2013/11/06)
A one-pot protocol for the asymmetric α-allylation reaction is reported relying on a key efficient asymmetric Claisen rearrangement, triggered by electrophilic activation of chiral pseudoephedrine amides. Subsequent reduction or hydrolysis of the resulting iminium ions provides highly enantioenriched α-allylic aldehydes or carboxylic acids in a traceless manner. Compared to traditional alternatives which make use of strongly basic conditions, the work presented herein displays unprecedented functional group tolerance.