73482-11-8Relevant articles and documents
Synthetic Studies on Antibiotic Validamycins. Part 11. Synthesis of Validamycin A
Ogawa, Seiichiro,Nose, Taisuke,Ogawa, Takao,Toyokuni, Tatsushi,Iwasawa, Yoshikazu,Suami, Tetsuo
, p. 2369 - 2374 (2007/10/02)
The antibiotic validamycin A (1a) has been synthesized for the first time (as its undeca-O-acetate) by glycosylation of the partially protected derivative (8) of the aglycone, validoxylamine A (2a), with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride (11), followed by deprotection, thereby establishing the structure previously assigned.The totally O-acetylated derivative (19) of 7-deoxyvalidamycin A has been synthesized in a similar fashion.