735-46-6

Basic information

• Product Name: hamaudol
• Synonyms: hamaudol;(S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
• CAS NO: 735-46-6
• Molecular Formula: C15H16O5
• Molecular Weight: 276.28454
• Mol File: 735-46-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 197.0-197.5 °C
• Boiling Point: 464.7°C at 760 mmHg
• Flash Point: 176°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 1.95E-09mmHg at 25°C
• Refractive Index: 1.603
• PKA: 6.77±0.70(Predicted)
• CAS DataBase Reference: hamaudol(CAS DataBase Reference)
• NIST Chemistry Reference: hamaudol(735-46-6)
• EPA Substance Registry System: hamaudol(735-46-6)

Safety Data

• Hazardous Substances Data: 735-46-6(Hazardous Substances Data)

Usage

General Description

"Hamaudol" is a chemical compound belonging to the family of nonsteroidal anti-inflammatory drugs (NSAIDs). It is commonly used for its analgesic, anti-inflammatory, and antipyretic properties. The main active ingredient in hamaudol is known as metacetamol, and it works by inhibiting the synthesis of prostaglandins, which are responsible for pain and inflammation in the body. Hamaudol is often prescribed for the treatment of mild to moderate pain, such as headaches, dental pain, and musculoskeletal pain. It is available in various forms, including tablets, capsules, and oral suspension, and is generally well-tolerated when used at the recommended dosage. However, like other NSAIDs, hamaudol may have potential side effects, including gastrointestinal irritation, cardiovascular risks, and kidney damage, so it should be used cautiously and under the supervision of a healthcare professional.

InChI:InChI=1/C15H16O5/c1-7-4-9(16)13-11(19-7)6-10-8(14(13)18)5-12(17)15(2,3)20-10/h4,6,12,17-18H,5H2,1-3H3/t12-/m0/s1

Upstream product

• 80681-44-3 3'-O-β-glucopyranosylhamaudol 

Relevant articles and documents

Identifying the compounds that can distinguish between Saposhnikovia root and its substitute, Peucedanum ledebourielloides root, using LC-HR/MS metabolomics

Abstract: Previously, we established a 1H NMR metabolomics method using reversed-phase solid-phase extraction column (RP-SPEC), and succeeded in distinguishing wild from cultivated samples of Saposhnikoviae radix (SR), and between SR and its substitute, Peucedanum ledebourielloides root (PR). Herein, we performed LC-HR/MS metabolomics using fractions obtained via RP-SPEC to identify characteristic components of SR and PR. One and three characteristic components were respectively found for SR and PR; these components were isolated with their m/z values and retention times as a guide. The characteristic component of SR was identified as 4′-O-β-d-glucosyl-5-O-methylvisamminol (1), an indicator component used to identify SR in the Japanese Pharmacopoeia. In contrast, the characteristic components of PR were identified as xanthalin (2), 4′-O-β-d-apiosyl (1 → 6)-β-d-glucosyl-5-O-methylvisamminol (3), and 3′-O-β-d-apiosyl (1 → 6)-β-d-glucosylhamaudol (4) based on spectroscopic data such as 1D- and 2D-NMR, MS, and specific optical rotation. Among them, 4 is a novel compound. For the correlation between the NMR metabolomics results in the present and our previous report, only 1 and 2 were found to correlate with the chemical shifts, and the other compounds had no correlation. As the chemical shifts for compounds 1, 3, and 4 were similar to each other, especially for the aglycone moiety, they could not be distinguished because of the sensitivity and resolution of 1H NMR. Accordingly, combining NMR and LC/MS metabolomics with their different advantages is considered useful for metabolomics of natural products. The series of methods used in our reports could aid in quality evaluations of natural products and surveying of marker components. Graphic abstract: [Figure not available: see fulltext.]

CHEMICAL STUDIES OF ANGELICA JAPONICA A. GRAY. I. ON THE CONSTITUENTS OF THE ETHYL ACETATE EXTRACT OF THE ROOT

The dried roots of Angelica japonica A.Gray (Umbelliferae) afforded three new chromones (VI, VIII and IX) together with six known chromones (I-V and VII) and fourteen known coumarins (X-XXIII) which were identified by comparison with authentic samples.The structure of VI, VIII and IX were established as (3S)-2,2-dimethyl-3,5-dihydroxy-8-hydroxymethyl-3,4-dihydro-2H,6H-benzodipyran-6-one, (3S)-2,2-dimethyl-3-β-D-glucosyloxy-5-hydroxy-8-methyl-3,4-dihydro-2H,6H-benzodipyran-6-one (sec-O-glucosylhamaudol) and (2S)-2-(1-hydroxy-1-methylethyl)-4-methoxy-7-β-D-glucosyloxymethyl-2,3-dihydro-5H-furobenzopyran-5-one (prim-O-glucosylcimifugin).Keywords: - Angelica japonica; chromone; coumarin; dihydropyranochromone; dihydrofurochromone; sec-O-glucosylhamaudol; prim-O-glucosylcimifugin