735271-14-4Relevant articles and documents
Intramolecular catalytic Friedel-Crafts reactions with allenyl cations for the synthesis of quinolines and their analogues
Ishikawa, Teruhiko,Manabe, Shinobu,Aikawa, Toshiaki,Kudo, Takayuki,Saito, Seiki
, p. 2361 - 2364 (2007/10/03)
(Equation Presented) This paper describes a novel method to synthesize a quinoline backbone by incorporating allenyl cations into a catalytic intramolecular Friedel-Crafts reaction. The initial products were isomerized and aromatized upon treatment with acid and base, respectively, to give quinolines. The basic concept also proved to be promising for 1-benzazepine, 1-benzazocine, or isoquinoline synthesis.