7353-59-5

Basic information

• Product Name: 2-[(Dimethylamino)methyl]tetralin-1-one
• Synonyms: 2-(Dimethylaminomethyl)-3,4-dihydronaphthalene-1(2H)-one;2-(Dimethylaminomethyl)tetralin-1-one;2-[(Dimethylamino)methyl]-3,4-dihydro-1(2H)-naphthalenone;2-[(Dimethylamino)methyl]tetralin-1-one;3,4-Dihydro-2-(dimethylaminomethyl)-1(2H)-naphthalenone;N-538;2-((dimethylamino)methyl)-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 7353-59-5
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.2802
• Mol File: 7353-59-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 308°Cat760mmHg
• Flash Point: 109.5°C
• Appearance: /
• Density: 1.047g/cm³
• Vapor Pressure: 0.000702mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 2-[(Dimethylamino)methyl]tetralin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(Dimethylamino)methyl]tetralin-1-one(7353-59-5)
• EPA Substance Registry System: 2-[(Dimethylamino)methyl]tetralin-1-one(7353-59-5)

Safety Data

• Hazardous Substances Data: 7353-59-5(Hazardous Substances Data)

Usage

Chemical class

Tetralin ketones

Synonym

DMTM

Physical state

Yellowish liquid

Molar mass

203.28 g/mol

Applications

Organic synthesis, drug research, pharmaceuticals and bioactive compounds development, chemical reactions reagent, and intermediate in compound production

Safety concerns

Potential health hazards and environmental risks, proper handling and safety measures required

InChI:InChI=1/C13H17NO/c1-14(2)9-11-8-7-10-5-3-4-6-12(10)13(11)15/h3-6,11H,7-9H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 7007-34-3 1-(3,4-dihydro-1-naphthalenyl)pyrrolidine 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 
• 30931-91-0 N,N-dimethylmethyleneammonium tetrachloroaluminate 
• 646-06-0 1,3-DIOXOLANE 
• 124-40-3 dimethyl amine 

Downstream Products

• 54669-72-6 2-(2-oxo-2-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one 
• 579490-30-5 2-[4-(2-benzhydryloxy-ethyl)-piperazin-1-ylmethyl]-3,4-dihydro-2H-naphthalen-1-one 
• 579490-32-7 2-(4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazin-1-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one 
• 125101-74-8 2,2-dibenzyloxy-1,9,10,10a-tetrahydro-3(2H)-phenanthrenone 
• 391652-92-9 E-(2RS)-[1-(2-Methoxybenzylidene)-1,2,3,4-tetrahydro-naphth-2-ylmethyl]-dimethylamine hydrochloride 

Relevant articles and documents

-

-

Further exploration of 1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}piperazine (GBR 12909): Role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter

A series of N-aromatic, N-heteroaromatic, and oxygenated N-phenylpropyl derivatives of 1-(2-benzhydryloxyethyl)-piperazine and 1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}piperazine, analogues of GBR 12909 (1a) and 12935 (1b), was synthesized and examined for their dopamine (DAT) and serotonin (SERT) transporter binding properties. One of these compounds, racemic 3-[4-(2-benzhydryloxyethyl)piperazin-1-yl]-1-(3-fluorophenyl)-propan-1-ol (33), had DAT affinity as good as, or better than, GBR 12909 and 12935, and was more selective for DAT over SERT than the GBR compounds. Both trans- (43) and cis- (47) (±)-2-(4-{2-[bis-(4-fluorophenyl)-methoxy]ethyl}piperazin-1- ylmethyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol had relatively good SERT selectivity and, as well, showed high affinity for SERT.

A synthetic approach to benanomicin A. 1. Synthesis of 5,6-dihydrobenzo[a] naphthacenequinone

5,6-Dihydrobenzo[a] naphthacenequinone has been constructed by DIELS-ALDER reaction of an outer-ring diene with a naphthoquinone regioselectively. Similarly, the 14-hydroxy-5,6-dihydrobenzo[a] naphthacenequinone has also been synthesized via the reaction of vinylketene acetal with naphthoquinone.