73534-58-4Relevant articles and documents
Application of Ugi three component reaction for the synthesis of quinapril hydrochloride
Borase, Bhushan B.,Godbole, Himanshu M.,Singh, Girij P.,Upadhyay, Pritesh R.,Trivedi, Anurag,Bhat, Varadaraj,Shenoy, Gautham G.
, p. 48 - 55 (2020)
A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.
Radical-Induced Reductive Deamination of Amino Acid Esters
Barton, Derek H. R.,Bringmann, Gerhard,Motherwell, Wiliam B.
, p. 68 - 70 (2007/10/02)
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