73551-24-3

Basic information

• Product Name: Propanamide, N,2,2-trimethyl-N-(phenylmethyl)-
• Synonyms: N-benzyl-N-methylpivaloylamide;N-Benzyl-N-methyltrimethylacetamide;Propanamide,N,2,2-trimethyl-N-(phenylmethyl)
• CAS NO: 73551-24-3
• Molecular Formula: C13H19NO
• Molecular Weight: 205.3
• Mol File: 73551-24-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Propanamide, N,2,2-trimethyl-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N,2,2-trimethyl-N-(phenylmethyl)-(73551-24-3)
• EPA Substance Registry System: Propanamide, N,2,2-trimethyl-N-(phenylmethyl)-(73551-24-3)

Safety Data

• Hazardous Substances Data: 73551-24-3(Hazardous Substances Data)

Upstream product

• 4210-60-0 t-butylmalonodinitrile 
• 103-67-3 benzyl-methyl-amine 
• 3282-30-2 pivaloyl chloride 
• 654651-48-6 2,2-dimethyl-propionic acid 4-oxo-4H-pyrido[3,2-d][1,2,3]triazin-3-yl ester 
• 654651-50-0 2,2-dimethyl-propionic acid 4-oxo-4H-pyrido[3,2-d]pyrimidin-3-yl ester 
• 72760-98-6 Me₃CCOOBt 
• 654651-49-7 2,2-dimethyl-propionic acid [1,2,3]triazolo[4,5-b]pyridin-3-yl ester 
• 442516-65-6 2,2-dimethyl-propionic acid 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl ester 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 6721-67-1 tert-butyl benzyl ketone 
• 105735-62-4 3,3-dimethyl-1-phenyl-2-butanol 
• 70785-32-9 N,N-dibenzyl-2,2-dimethylpropanethioamide 
• 1944-01-0 1-benzylcyclohexan-1-ol 
• 197958-51-3 2,2,N-Trimethyl-N-(1-phenyl-ethyl)-propionamide 
• 68723-29-5 N-methyl-N-(2,2-dimethylpropyl)benzylamine 
• 6830-83-7 N-methyl-pivalamide 

Relevant articles and documents

Sterically Demanding Oxidative Amidation of α-Substituted Malononitriles with Amines Using O2

An efficient amidation method between readily available 1,1-dicyanoalkanes and either chiral or nonchiral amines was realized simply with molecular oxygen and a carbonate base. This oxidative protocol can be applied to both sterically and electronically challenging substrates in a highly chemoselective, practical, and rapid manner. The use of cyclopropyl and thioether substrates support the radical formation of α-peroxy malononitrile species, which can cyclize to dioxiranes that can monooxygenate malononitrile α-carbanions to afford activated acyl cyanides capable of reacting with amine nucleophiles.

Practical access to amines by platinum-catalyzed reduction of carboxamides with hydrosilanes: Synergy of dual Si-H groups leads to high efficiency and selectivity

The synergetic effect of two Si-H groups leads to efficient reduction of carboxamides to amines by platinum catalysts under mild conditions. The rate of the reaction is dependent on the distance of two Si-H groups; 1,1,3,3-tetramethyldisiloxane (TMDS) and 1,2-bis(dimethylsilyl)benzene are found to be an effective reducing reagent. The reduction of amides having other reducible functional groups such as NO2, CO2R, CN, CdC, Cl, and Br moieties proceeds with these groups remaining intact, providing a reliable method for the access to functionalized amine derivatives. The platinum-catalyzed reduction of amides with polymethylhydrosiloxane (PMHS) also proceeds under mild conditions. The reaction is accompanied by automatic removal of both platinum and silicon wastes as insoluble silicone resin, and the product is obtained by simple extraction. A mechanism involving double oxidative addition of TMDS to a platinum center is discussed.

Generation of allylic and benzylic organolithium reagents from the corresponding ester, amide, carbonate, carbamate and urea derivatives

The reaction of different allylic and benzylic non-enolisable esters or amides (1), carbonates (4), carbamates (6, 7) and ureas (8) with an excess of lithium powder and a catalytic amount of naphthalene (10%) in the presence of an electrophile [(i)PrCHO, (t)BuCHO, PhCHO, Me2CO, Et2CO, (CH2)5CO, Ph2CO, Me3SiCl] in THF at different temperatures (-78, -30 or 0°C) leads, after hydrolysis with water to the corresponding allylated or benzylated products (2).