73604-40-7

Basic information

• Product Name: α-Methyl-β-phenylstyryl acetate
• CAS NO: 73604-40-7
• Molecular Weight: 252.313
• Mol File: 73604-40-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α-Methyl-β-phenylstyryl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: α-Methyl-β-phenylstyryl acetate(73604-40-7)
• EPA Substance Registry System: α-Methyl-β-phenylstyryl acetate(73604-40-7)

Safety Data

• Hazardous Substances Data: 73604-40-7(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 2036-66-0 Dilithium benzophenone dianion 
• 781-35-1 1,1-diphenylacetone 
• 119-61-9 benzophenone 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 143747-51-7 1-(2-oxo-3,3-diphenylpropyl)-3-piperidinecarboxylic acid 
• 143747-35-7 Acetic acid 1-bromomethyl-2,2-diphenyl-vinyl ester 

Relevant articles and documents

Structure-Activity Studies on Benzhydrol-Containing Nipecotic Acid and Guvacine Derivatives as Potent, Orally-Active Inhibitors of GABA Uptake

The introduction of lipophilic groups onto the ring nitrogen of nipecotic acid and guvacine, two known GABA uptake inhibitors, afforded potent, orally-active anticonvulsant drugs.A series of compounds is reported which explores the structure-activity relationships (SAR) in this series.Among the areas explored: side-chain SAR (aromatic-, heterocyclic-, and tricyclic-containing side chains) and modifications to the tetrahydropyridine ring.The benzhydrol ether-containing side chains afforded the most potent compounds with several exhibiting in vitro IC50 values for GABA uptake of 1 μM (including 5, Table I; 37, 43, Table IV; and 44, Table V).Compound 44 was selected for extensive evaluation and subsequently progressed to Phase 1 clinical trials with severe adverse effects seen after single dose administration to humans.

REACTION OF DILITHIUM BENZOPHENONE, DILITHIUM 9-FLUORENONE AND THE LITHIUM SALT OF BENZOPHENONE KETYL WITH CHLORIDES AND ANHYDRIDES OF CARBOXYLIC ACIDS

The reaction of dilithium benzophenone and the lithium salt of benzophenone ketyl with anhydrides and chlorides of benzoic and acetic acid and the reaction of dilithium 9-fluorenone with acetic anhydride were investigated.In addition to the expected products Ar2C(COR)OCOR, products of the type Ar2C=CR(OCOR) were also obtained, and in the case of reactions with acetyl chloride and acetic anhydride, products of the type Ar2CH(OCOR).ESR studies showed that ketyl is formed in the reaction of dilithium benzophenone with acetic anhydride, and the ClDNP method revealed thatbenzhydryl acetate is formed, at least in part, by hydrogen transfer to a free radical produced by O-acetylation of the ketyl.The results suggest a competition between addition and electron transfer reactions.