7363-25-9Relevant articles and documents
Bioinspired enantioselective synthesis of crinine-type alkaloids: Via iridium-catalyzed asymmetric hydrogenation of enones
Zuo, Xiao-Dong,Guo, Shu-Min,Yang, Rui,Xie, Jian-Hua,Zhou, Qi-Lin
, p. 6202 - 6206 (2017/08/29)
A bioinspired enantioselective synthesis of crinine-type alkaloids has been developed by iridium-catalyzed asymmetric hydrogenation of racemic cycloenones. The method features a biomimetic stereodivergent resolution of the substrates bearing a remote arylated quaternary stereocenter. Using this protocol, 24 crinine-type alkaloids and 8 analogues were synthesized in a concise and rapid way with high yield and high enantioselectivity.