73638-56-9

Basic information

• Product Name: 1-[⁷⁷Br]bromo-4-methoxy-benzene
• Synonyms: 1-[⁷⁷Br]bromo-4-methoxy-benzene
• CAS NO: 73638-56-9
• Molecular Weight: 184.132
• Mol File: 73638-56-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[⁷⁷Br]bromo-4-methoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[⁷⁷Br]bromo-4-methoxy-benzene(73638-56-9)
• EPA Substance Registry System: 1-[⁷⁷Br]bromo-4-methoxy-benzene(73638-56-9)

Safety Data

• Hazardous Substances Data: 73638-56-9(Hazardous Substances Data)

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 79-21-0 peracetic acid 
• 16759-25-4 [⁷⁷Br]bromide 
• 940-00-1 (4-methoxyphenyl)trimethylstannane 
• 14476-81-4 (4-methoxyphenyl)trimethylgermane 
• 877-68-9 4-trimethylsilylanisole 

Relevant articles and documents

Copper-mediated nucleophilic radiobromination of aryl boron precursors: Convenient preparation of a radiobrominated PARP-1 inhibitor

The copper-mediated nucleophilic radiobromination of aryl boron precursors with a radiobromide ion is a novel radiolabeling method that is efficient and robust. High radiochemical conversion (RCC) was observed using a variety of solvents, temperatures and catalysts. The reaction is also clean and is feasible for purification to obtain high chemical and radiochemical purity. This method provides a very useful route for the preparation of radiobrominated pharmaceuticals, including a radiobromine labeled PARP-1 inhibitor, and it is a valuable addition to the family of copper-mediated radiolabeling processes.

Regiospecific No-Carrier-Added Radiobromination and Radioiodination of Arylmethyl Group IVb Organometallics

A series of para-substituted aryltrimethyl-silicon, -germanium, and -tin compounds were treated at room temperature with no-carrier-added (n.c.a.) 77Br and 131I to compare their utility as substrates for regiospecific aromatic halogenation.Dichloramine-T was used as an in situ oxidant in acidic, polar, or non-polar reaction solvents.N.c.a. aromatic halodemetallation was regiospecific for all substrates, radiochemical yields were generally higher for 131I than 77Br, and halogenation yields increased as Si Ge Sn.Arguments are presented for a substitution mechanism involving a ?-complex intermediate with bond formation as the yield-determinig step.Although high yields were obtained for the n.c.a. aromatic halogenodestannylations irrespective of aromatic substituent or solvent, significant chlorination occured as a side-reaction.N.c.a. aromatic halogenodegermylation produced high radiochemical yields with insignificant chlorination, but the radiohalogenation yields were sensitive to ring deactivation and solvent effects.N.c.a. aromatic halogenodesilylation gave high yields only in activated aromatic systems.The relative benefits of each demetallation reaction for regiospecific n.c.a. radiolabelling or preparative halogenation of aromatic rings are outlined.