73663-56-6Relevant articles and documents
Oxazoles in Organic Chemistry. 2. Application to the Synthesis of Benzylisoquinoline Alkaloids
Kozikowski, Alan P.,Ames, Anthony
, p. 2548 - 2550 (1980)
A conceptually new route to the benzylisoquinoline alkaloids has been devised.The reaction of 2-lithiooxazoles with aromatic aldehydes to generate the thermodynamically favored 2-substituted oxazoles constitutes the key step in this process.A single-pot two carbon-carbon bond-joining reaction leading to an oxazoline suitable for further transformation to a phenethylamide is also described.