73670-26-5

Basic information

• Product Name: cholest-5-en-3-yl glycinate
• CAS NO: 73670-26-5
• Molecular Formula: C₂₉H₄₉NO₂
• Molecular Weight: 443.7049
• Mol File: 73670-26-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 517.3°C at 760 mmHg
• Flash Point: 317.5°C
• Density: 1.02g/cm³
• Vapor Pressure: 8.3E-11mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: cholest-5-en-3-yl glycinate(CAS DataBase Reference)
• NIST Chemistry Reference: cholest-5-en-3-yl glycinate(73670-26-5)
• EPA Substance Registry System: cholest-5-en-3-yl glycinate(73670-26-5)

Safety Data

• Hazardous Substances Data: 73670-26-5(Hazardous Substances Data)

Upstream product

• 57-88-5 cholesterol 
• 2184-96-5 glycinyl chloride hydrochloride 
• 3464-50-4 chloroacetic acid cholesterylester 
• 73670-11-8 cholesterol t-butyloxycarbonylaminoacetate 
• 57-88-5 cholesterol 

Relevant articles and documents

Self-aggregates of cholesterol-modified carboxymethyl konjac glucomannan conjugate: Preparation, characterization, and preliminary assessment as a carrier of etoposide

Various cholesterol (CH) bearing carboxymethyl konjac glucomannan (CKGM) amphiphilic conjugates (denoted CHCKGM) were synthesized using CKGM as hydrophilic segments and CH as hydrophobic parts. Structural characteristics of these CHCKGM conjugates were in

Synthesis and gelation behaviors of five new dimeric cholesteryl derivatives

Five new diacid amides of di-cholesteryl l-glycinates were designed and prepared. The compounds with linkers containing 0, 1, 2, 3, or 4 methylene units are denoted as 1, 2, 3, 4, and 5, respectively. Their gelation behaviors in 25 solvents were tested as novel low-molecular-mass organic gelators (LMOGs). It was shown that the length of the linker connecting the two-cholesteryl residues in a gelator plays a crucial role in the gelation behavior of the compound. 1 gels 11 of the 25 solvents tested at a concentration lower than 1.0%, while 2 gels 17 of the solvents tested. 4 and 5, however, gel only 2 and 4 of them, respectively. SEM observation reveals that the lengths of the linkers and the identity of the solvents are the main factors affecting the structures of the aggregates in the gels. Experimentally, a clear linker effect on the microstructures of the gels was observed. As example, the aggregates of 1, 2 and 3 in benzene or 1-heptanol adopt structures of thin fibers, rods or lamellas, respectively. Furthermore, it was found that the gelation and aggregation behaviors of 2, 3, 4, and 5 in DMSO showed an even-odd effect.

Hyaluronic acid-glycine-cholesterol conjugate-based nanoemulsion as a potent vaccine adjuvant for T cell-mediated immunity

Clinical cases of allergic reaction that are due to excipients containing polyethylene glycol (PEG), a hydrophilic molecule commonly used in drug/vaccine formulations, has attracted much attention in recent years. In order to develop PEG-free adjuvants, we investigated the feasibility of natural ingredients in the human body such as hyaluronic acid in the form of hyaluronic acid-glycine cholesterol (HACH) conjugate as an excipient for vaccine formulation. Interestingly, HACH grafted with ~13 wt.% cholesterol has good water dispersity and can serve as an emulsifier to stabilize the squalene/water interfaces, yielding a milky white and isotropic emulsion (SQ@HACH) after being passed through a high-shear microfluidizer. Our results show that SQ@HACH particles possessed a unimodal average hydrodynamic diameter of approximately 190 nm measured by dynamic light scattering and exhibited good stability upon storage at 4?C and 37?C for over 20 weeks. The results of immunogenicity using a mouse model with ovalbumin (OVA) as the antigen revealed that SQ@HACH significantly enhanced antigen-specific immune responses, including the polarization of IgG antibodies, the cytokine secretions of T cells, and enhancement of cytotoxic T lymphocyte (CTL) activation. Moreover, SQ@HACH revealed lower local inflammation and rapidly absorbing properties compared with AlPO4 after intramuscular injection in vivo, indicating the potential functions of the HA-derived conjugate as an excipient in vaccine formulations for enhancement of T cell-mediated immunity.

Naphthalene-cholesterol conjugate as simple gelator for selective sensing of CN– ion

Cholesterol-based Schiff base 1 has been designed and synthesised. The Schiff base 1 forms yellow coloured gel in DMF:H2O (2:1, v/v) and the gel is anion responsive. Among different anions, the gel phase of 1 is selectively transformed into sol in the presence of CN– ions and validates its visual sensing. 1H NMR, FTIR and HRMS spectroscopic techniques were adopted to study the gelation of 1 and its responsive behaviour towards anions.