73681-14-8

Basic information

• Product Name: 2,3-Dihydro-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione
• Synonyms: 2,3-Dihydro-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione;5-VANILLYLIDENE-2-THIOBARBITURIC ACID;5-(4-hydroxy-3-methoxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• CAS NO: 73681-14-8
• Molecular Formula: C₁₂H₁₀N₂O₄S
• Molecular Weight: 278.28
• Mol File: 73681-14-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 493.2°C at 760 mmHg
• Flash Point: 252.1°C
• Appearance: /
• Density: 1.54g/cm³
• Vapor Pressure: 1.52E-10mmHg at 25°C
• Refractive Index: 1.703
• CAS DataBase Reference: 2,3-Dihydro-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione(73681-14-8)
• EPA Substance Registry System: 2,3-Dihydro-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione(73681-14-8)

Safety Data

• Hazardous Substances Data: 73681-14-8(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione is a chemical compound with potential pharmaceutical applications. It is a derivative of 2-thioxo-4,6(1H,5H)-pyrimidinedione, which is known for its antimicrobial, antiviral, and antitumor properties. The presence of a hydroxy and methoxy group on the benzene ring suggests potential antioxidant and anti-inflammatory activity. Additionally, the compound contains a thioxo group, which may contribute to its biological effects. Overall, 2,3-Dihydro-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxo-4,6(1H,5H)-pyrimidinedione has the potential to be developed into a drug with various therapeutic uses.

InChI:InChI=1/C12H10N2O4S/c1-18-9-5-6(2-3-8(9)15)4-7-10(16)13-12(19)14-11(7)17/h2-5,15H,1H3,(H2,13,14,16,17,19)

Upstream product

• 504-17-6 4,6-dihydroxy-2-mercaptopyrimidine 
• 121-33-5 vanillin 

Relevant articles and documents

Composition for trichogenousness

The present invention relates to novel barbiturate and thiobarbiturate derivatives and a composition for promoting hair growth using the same. According to the present invention, the barbiturate and thiobarbiturate derivatives, in an animal model, have shown to promote hair growth and have excellent effects on hair growth by promoting regulation of Wnt/andbeta;-catenin and hair growth factor signaling and suppressing mechanism of apoptosis. Accordingly, the barbiturate and thiobarbiturate derivatives of the present invention may be used as a composition for promoting hair growth.COPYRIGHT KIPO 2017

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

New strategy for the synthesis of 5-Aryl-1H,1′H-spiro[furo[2,3-d] pyrimidine-6,5′-pyrimidine]2,2′,4,4′,6′(3H,3'H,5H) -pentaones and their sulfur analogues

Reaction of barbituric acid (BA), 1,3-dimethyl barbituric acid (DMBA) and 2-thiobarbituric acid (TBA) with cyanogen bromide and aldehydes in the presence of L-(+)-tartaric acid afforded a new route for the synthesis of stable heterocyclic 5-aryl-1H,1′H-spiro[furo[2,3-d]pyrimidine-6,5′- pyrimidine]2,2′,4,4′,6′(3H,3′H,5H)- pentaones which is a dimeric form of barbiturate (uracil and thiouracil derivative). In the reaction of 1,3-diethyl thiobarbituric acid (DETBA) the Knoevenagel condensation and then Michael adducts were obtained under the same condition. Structure elucidation is carried out by 1H NMR, 13C NMR, FT-IR and Mass analyses. Mechanism of the formation is discussed.