73684-70-5 Usage
Description
Antibiotic A 11725 III is a mycinamicin antibiotic that consists of a 16-membered ring macrolactone core, an N,N-dimethylated deoxysugar desosamine, and a 2-O-methylated 6-deoxysugar javose. It is known for its potent antimicrobial properties and has been extensively studied for its potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
Antibiotic A 11725 III is used as an antimicrobial agent for treating bacterial infections. Its unique structure and mechanism of action make it effective against a wide range of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). It works by inhibiting protein synthesis in bacteria, leading to their death.
Used in Agricultural Industry:
Antibiotic A 11725 III is used as a growth promoter and feed additive in livestock farming. It helps to improve the overall health and growth of animals by preventing and treating bacterial infections, thus reducing the need for antibiotics in animal husbandry.
Used in Cosmetic Industry:
Antibiotic A 11725 III is used as a preservative in cosmetic products to prevent microbial contamination and extend the shelf life of the products. Its broad-spectrum antimicrobial activity makes it an effective ingredient in skincare and personal care products.
Used in Food Industry:
Antibiotic A 11725 III is used as a food preservative to prevent spoilage and extend the shelf life of various food products. Its ability to inhibit the growth of bacteria and other microorganisms helps maintain the quality and safety of food items.
Used in Environmental Industry:
Antibiotic A 11725 III is used in wastewater treatment and disinfection processes to control the growth of harmful microorganisms and maintain a clean and healthy environment. Its antimicrobial properties make it a valuable tool in combating waterborne diseases and promoting environmental sustainability.
Check Digit Verification of cas no
The CAS Registry Mumber 73684-70-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,6,8 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 73684-70:
(7*7)+(6*3)+(5*6)+(4*8)+(3*4)+(2*7)+(1*0)=155
155 % 10 = 5
So 73684-70-5 is a valid CAS Registry Number.
InChI:InChI=1/C36H59NO11/c1-10-28-25(19-44-36-34(43-9)32(42)30(40)24(6)46-36)13-11-12-14-27(38)21(3)17-22(4)33(20(2)15-16-29(39)47-28)48-35-31(41)26(37(7)8)18-23(5)45-35/h11-16,20-26,28,30-36,40-42H,10,17-19H2,1-9H3/b13-11+,14-12+,16-15+
73684-70-5Relevant articles and documents
Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O -Methyltransferases
Bernard, Steffen M.,Akey, David L.,Tripathi, Ashootosh,Park, Sung Ryeol,Konwerski, Jamie R.,Anzai, Yojiro,Li, Shengying,Kato, Fumio,Sherman, David H.,Smith, Janet L.
, p. 1340 - 1351 (2015)
Sugar moieties in natural products are frequently modified by O-methylation. In the biosynthesis of the macrolide antibiotic mycinamicin, methylation of a 6′-deoxyallose substituent occurs in a stepwise manner first at the 2′- and then the 3′-hydroxyl groups to produce the mycinose moiety in the final product. The timing and placement of the O-methylations impact final stage C-H functionalization reactions mediated by the P450 monooxygenase MycG. The structural basis of pathway ordering and substrate specificity is unknown. A series of crystal structures of MycF, the 3′-O-methyltransferase, including the free enzyme and complexes with S-adenosyl homocysteine (SAH), substrate, product, and unnatural substrates, show that SAM binding induces substantial ordering that creates the binding site for the natural substrate, and a bound metal ion positions the substrate for catalysis. A single amino acid substitution relaxed the 2′-methoxy specificity but retained regiospecificity. The engineered variant produced a new mycinamicin analog, demonstrating the utility of structural information to facilitate bioengineering approaches for the chemoenzymatic synthesis of complex small molecules containing modified sugars. Using the MycF substrate complex and the modeled substrate complex of a 4′-specific homologue, active site residues were identified that correlate with the 3′ or 4′ specificity of MycF family members and define the protein and substrate features that direct the regiochemistry of methyltransfer. This classification scheme will be useful in the annotation of new secondary metabolite pathways that utilize this family of enzymes.
