737-86-0

Basic information

• Product Name: pyridoxal isonicotinoyl hydrazone
• Synonyms: Pyridoxal isonicotinoyl hydrazone (PIH)
• CAS NO: 737-86-0
• Molecular Formula: C₁₄H₁₄N₄O₃
• Molecular Weight: 286.29
• Mol File: 737-86-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: +2C to +8C
• CAS DataBase Reference: pyridoxal isonicotinoyl hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: pyridoxal isonicotinoyl hydrazone(737-86-0)
• EPA Substance Registry System: pyridoxal isonicotinoyl hydrazone(737-86-0)

Safety Data

• Hazardous Substances Data: 737-86-0(Hazardous Substances Data)

Usage

Uses

Pyridoxal Isonicotinoyl Hydrazone is a cell-permeable non-toxic iron chelator of the aroyl hydrazone class.

General Description

A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.

Upstream product

• 54-85-3 isoniazid 
• 65-22-5 pyridoxal hydrochloride 

Relevant articles and documents

Synthesis and characterization of diorganotin (IV) complexes with tridentate schiff base ligand pyridoxal aroylhydrazones

Dichlorodiorganotin (IV) R2SnCl2 (where R = Me, Bu, or Ph) on reaction with substituted hydrazones (H2L) derived from the condensation of pyridoxal hydrochloride with substituted acid hydrazides, H2pydx-inh (LI), H2pydx-th (LII), or H2pydx-nh (LIII) (pydx = pyridoxal, inh = isonicotinoyl hydrazone, th = 2-thiophene carboxyl hydrazone, nh = 1-naphthoyl hydrazone), dry benzene give pentacoordinated complexes of the type R2SnL(I-III). In the solution of isolated complexes the ligand acted in a tridentate manner (O,O,N), coordinating through a phenolic oxygen, oxygen of keto group after enolization, and nitrogen of azomethine group. The synthesized complexes were characterized by elemental analyses, molar conductance, molecular weight determination, and infrared (IR) and nuclear magnetic resonance (NMR; 1H, 13C, and 119Sn) spectral data. The ligands and their tin complexes were evaluated for antifungal and antibacterial activities, and the results indicate that they exhibit significant antimicrobial properties. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone and analogs thereof

Methods of inhibiting fibrosis comprising administering certain pyridoxal benzoyl hydrazones or analogs thereof are disclosed. Preferred hydrazones are pyridoxal benzoyl hydrazone, 3-hydroxyisonicotinaldehyde benzoyl hydrazone and salicylaldehyde benzoyl hydrazone. The methods are useful in treating fibrosing disorders, including dermal fibrosing disorders, fibrosis of internal organs and fibrotic conditions of the eye.