7374-34-7

Basic information

• Product Name: 4'-METHYL[1,1'-BIPHENYL]-2-OL
• Synonyms: AKOS BAR-1204;4'-METHYL[1,1'-BIPHENYL]-2-OL;4-Methylbiphenyl-2-ol
• CAS NO: 7374-34-7
• Molecular Formula: C₁₃H₁₂O
• Molecular Weight: 184.23
• Mol File: 7374-34-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-METHYL[1,1'-BIPHENYL]-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-METHYL[1,1'-BIPHENYL]-2-OL(7374-34-7)
• EPA Substance Registry System: 4'-METHYL[1,1'-BIPHENYL]-2-OL(7374-34-7)

Safety Data

• Hazardous Substances Data: 7374-34-7(Hazardous Substances Data)

Upstream product

• 94892-46-3 2-Benzyl-1,4-dimethyl-pyridinium; iodide 
• 87842-96-4 6-diazo-3-methylcyclohexa-2,4-dien-1-one 
• 5747-23-9 2-phenyl-1,3,2-benzodioxaborole 

Relevant articles and documents

Transition-Metal-Free C(sp2)–C(sp2) Cross-Coupling of Diazo Quinones with Catechol Boronic Esters

A transition-metal-free C(sp2)?C(sp2) bond formation reaction by the cross-coupling of diazo quinones with catechol boronic esters was developed. With this protocol, a variety of biaryls and alkenyl phenols were obtained in good to high yields under mild conditions. The reaction tolerates various functionalities and is applicable to the derivatization of pharmaceuticals and natural products. The synthetic utility of the method was demonstrated by the short synthesis of multi-substituted triphenylenes and three bioactive natural products, honokiol, moracin M, and stemofuran A. Mechanistic studies and density functional theory (DFT) calculations revealed that the reaction involves attack of the boronic ester by a singlet quinone carbene followed by a 1,2-rearrangement through a stepwise mechanism.